4-Hydroxyacetophenone Solubility via Glycerol Esters
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Solution Overview
Problem
Current skin care products, including cosmetics and dermatological preparations, often fail to provide a sustainable and physiological regeneration of the skin's natural barrier function, leading to temporary or limited hydration and protection against environmental stressors, and may worsen skin conditions upon discontinuation.
Innovation Solution
Combining 4-hydroxyacetophenone with glycerol and/or oligoglycerol esters of branched-chain and/or unbranched-chain alkanecarboxylic acids to enhance solubility and efficacy in cosmetic and dermatological preparations, thereby improving skin hydration and barrier restoration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If 4-hydroxyacetophenone is used as an antioxidant in cosmetic preparations, then skin protection against oxidative stress is improved, but its solubility in cosmetic solvents remains moderate, limiting its use concentration
Solution Approach 1:
The patent uses glyceryl caprylate as an intermediary substance to enhance the solubility of 4-hydroxyacetophenone in cosmetic preparations. The glyceryl caprylate acts as a mediator between the antioxidant and the cosmetic solvent system, allowing higher concentrations of 4-hydroxyacetophenone to be dissolved without compromising the formulation's stability or efficacy.
2Duration of action of moving object
If conventional skin care products are used, then temporary hydration is achieved, but sustainable regeneration of the skin's natural barrier function is not provided
Solution Approach 1:
The patent changes the chemical parameters of the formulation by combining 4-hydroxyacetophenone with glyceryl caprylate, creating a synergistic active ingredient combination that not only provides hydration but also supports the sustainable regeneration of the skin's natural barrier function through enhanced antioxidant protection and improved solubility characteristics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly increases the solubility of 4-hydroxyacetophenone, providing enhanced skin hydration and barrier restoration, leading to improved skin health and protection against environmental stressors, with potential for long-lasting effects.
Implementation Method 1
it was surprisingly found that active ingredient combinations consisting of one or more such glycerol and/or oligoglycerol esters of branched-chain and/or unbranched-chain alkanecarboxylic acids and 4-hydroxyacetophenone... remedy the disadvantage of moderate solubility
Data Source
AI summary
The invention relates to active-ingredient combinations consisting of one or more glycerin and/or oligoglycerin esters of branched chains and/or unbranched chains of alkane carboxylic acids and 4-hydroxyacetophenone, and to cosmetic or dermatological preparations containing said active-ingredient combinations.