A chitosan based fiber material, preparing method and application thereof
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Solution Overview
Problem
Current hemostatic materials, such as glutin sponge, collagen sponge, fibrin glue, and oxycellulose, are ineffective for controlling serious blood exudation, pose risks of disease transmission, and lack promotional effects on wound healing, while chitosan-based materials are limited by water solubility and slow degradation, causing inflammatory reactions.
Innovation Solution
Development of a water-soluble chitosan-based fiber material, including carboxymethyl, hydroxypropyl, and carboxymethyl hydroxyethyl chitosan fibers, processed to enhance hygroscopicity and biodegradability, allowing for rapid hemostasis, wound healing, and tissue adhesion prevention without immunogenicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If chitosan-based materials are used for hemostasis, then hemostatic effect is achieved, but water solubility is poor and degradation is slow causing inflammatory reactions
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of chitosan through carboxymethylation, hydroxypropylation, or hydroxyethyllation. These chemical modifications change the physical and chemical parameters of chitosan, specifically improving water solubility and adjusting degradation rate to prevent inflammatory reactions while maintaining hemostatic efficacy.
Solution Approach 2:
The patent creates composite materials by combining chitosan with other compounds through chemical modification. The resulting carboxymethyl chitosan, hydroxypropyl chitosan, or hydroxyethyl chitosan represent composite structures that integrate the hemostatic properties of chitosan with improved solubility and controlled degradation characteristics of the modifying groups.
2Reliability
If conventional hemostatic materials like glutin sponge or collagen sponge are used, then hemostatic effect is achieved, but risk of disease transmission and immunogenicity increases
Solution Approach 1:
The patent employs a disposable single-use hemostatic material made from chemically modified chitosan that can be discarded after one use. This eliminates the risk of disease transmission between patients and removes the need for sterilization processes, while the material provides effective hemostasis during the procedure.
Solution Approach 2:
The patent changes the material source from animal-derived products (glutin, collagen) to chemically modified chitosan, which is derived from chitin through controlled chemical processes. This parameter change in material origin eliminates the risk of animal viral diseases and reduces immunogenicity while maintaining hemostatic functionality.
3Reliability
If oxycellulose hemostatic material is used, then hemostatic effect for slight blood exudation is achieved, but hemostasis is slow for serious blood exudation
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of chitosan to enhance its interaction with blood components. The carboxymethyl, hydroxypropyl, or hydroxyethyl groups alter the charge distribution and molecular conformation, enabling faster hemostatic action for serious blood exudation while maintaining effectiveness for slight exudation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The water-soluble chitosan-based fibers effectively control bleeding, promote wound healing, prevent tissue adhesion, and degrade quickly, ensuring safety and efficacy in clinical applications with improved mechanical strength and handling.
Implementation Method 1
a water-insoluble chitosan fiber material is immersed in an aqueous solution of NaOH or KOH having a concentration of 20-50% by weight, preferably 30-45% by weight, and alkalized at a temperature ranging from -40°C to room temperature for 2 to 72 hours
Implementation Method 2
the alkalized water-insoluble chitosan-based fiber material is reacted with halogenated acetic acid, or halogenated ethanol, or propylene oxide, or halogenated propanol, or combination of halogenated acetic acid and halogenated ethanol in a reaction medium for a period of 5 to 36 hours
Implementation Method 3
The polymeric monomer of the carboxymethyl chitosan fiber has a degree of substitution of carboxyl of 1 to 50%, imparting the fiber a high hygroscopicity while maintaining a fibrous structure and thus its dissolubility in water
Implementation Method 4
Chitosan powder, chitosan membrane, chitosan sponge, and chitosan non-woven and woven fabrics obtained from chitosan degrade slowly in human body, and the complete degradation thereof takes over half a year
Data Source
AI summary
The invention relates to a medical material, especially to a hemostatic and wound-healing water-soluble chitosan-based fiber material. The water-soluble chitosan-based fiber material comprises carboxymethyl chitosan fiber, hydroxypropyl chitosan fiber, hydroxyethyl chitosan fiber, carboxymethyl hydroxyethyl chitosan fiber or mixtures thereof.