Reduced-Pressure Abdominal Drainage for Inflammatory Response Control
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Solution Overview
Problem
Current methods for managing systemic inflammatory response syndrome (SIRS) are costly and often delayed due to the severity of interventions like surgical decompression, which can lead to complications such as abdominal compartment syndrome and multiple organ dysfunction.
Innovation Solution
A system and method for controlling inflammatory responses by removing pro-inflammatory stimuli, enhancing tissue perfusion, and providing reduced-pressure therapy to disrupt the inflammatory environment, including the use of a treatment device with encapsulated leg members and a manifold for fluid management within the abdominal cavity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If surgical decompression is performed to control SIRS, then inflammatory response is reduced, but patient morbidity and mortality increase due to the severity of the intervention
Solution Approach 1:
The patent extracts and removes pro-inflammatory stimuli (fluids, toxins, cytokines) directly from the abdominal cavity using a drainage system with collection devices, rather than performing surgical decompression. This extraction approach reduces inflammatory response while avoiding the morbidity associated with major surgery.
Solution Approach 2:
The patent introduces an intermediary drainage system that mediates between the inflammatory environment and the patient's systemic circulation. The collection devices and drainage tubes act as intermediaries to remove inflammatory mediators before they can cause widespread organ damage, providing a less invasive alternative to surgical decompression.
2Reliability
If surgical decompression is delayed to avoid severe intervention, then patient morbidity is reduced, but inflammatory response progresses leading to organ dysfunction
Solution Approach 1:
The patent implements preliminary action by establishing the drainage system early in the course of SIRS, before inflammatory damage becomes irreversible. The continuous removal of pro-inflammatory stimuli prevents the progression to organ dysfunction while avoiding the need for later surgical intervention.
Solution Approach 2:
The patent employs continuous drainage and fluid removal to maintain ongoing control of the inflammatory response. This continuous action ensures that pro-inflammatory stimuli are consistently removed over time, preventing the progression to organ dysfunction without requiring repeated surgical interventions.
3Stress or pressure
If laparotomy is performed for abdominal compartment syndrome, then intra-abdominal pressure is reduced, but hospital stay and treatment cost increase
Solution Approach 1:
The patent replaces the mechanical intervention of laparotomy (surgical incision and manual decompression) with a less invasive drainage system that uses gravitational and pressure gradients to remove fluids and reduce intra-abdominal pressure. This substitution maintains pressure control while avoiding the morbidity and extended hospitalization associated with surgery.
4Reliability
If early intervention is implemented to control inflammatory response, then progression to organ dysfunction is prevented, but more invasive procedures may be required
Solution Approach 1:
The patent applies partial action by implementing a targeted drainage system that addresses the specific problem of fluid accumulation and pro-inflammatory stimulus removal, rather than performing comprehensive surgical decompression. This partial intervention is sufficient to control the inflammatory response and prevent organ dysfunction without the excessive invasiveness of full laparotomy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Effectively controls inflammatory responses by reducing pro-inflammatory stimuli and maintaining intra-abdominal pressure, thereby preventing complications like abdominal compartment syndrome and multiple organ dysfunction, allowing for earlier and less invasive intervention.
Implementation Method 1
a reduced-pressure source in communication with the treatment device and operable to remove pro-inflammatory stimuli from the abdominal cavity
Implementation Method 2
providing reduced-pressure therapy to disrupt the inflammatory environment
Data Source
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AI summary
A method and system for controlling inflammatory response at an internal tissue site of a patient utilizes a reduced-pressure treatment device. Controlling the inflammatory response may be accomplished in a number of ways that involve treating the inflammatory milieu. Treating the inflammatory milieu may include removing or moderating pro-inflammatory stimuli, e.g., fluids, enhancing perfusion of the tissue at or near the internal tissue site, or providing reduced-pressure therapy. The reduced-pressure treatment device is placed at or near the internal tissue site and is fluidly coupled to an external reduced-pressure source. The reduced-pressure treatment device provides reduced pressure proximate the tissue site and treats the inflammatory milieu. The reduced-pressure treatment device for controlling inflammatory response may be a minimally-invasive treatment device.