Absorbable Putty Bone Wax for Hemostasis and Osteogenesis
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Solution Overview
Problem
Current surgical methods for controlling osseous hemorrhage and promoting bone healing are inadequate, as existing bone hemostatic agents are either non-absorbable, ineffective in inducing bone growth, or cause tissue damage, while materials for bone defect healing lack reliable adherence and osteogenic properties.
Innovation Solution
Development of absorbable, putty-like compositions combining carboxylic acid salts with specific dispersing vehicles, optionally including demineralized bone matrix and anti-infective agents, which provide mechanical hemostasis and osteogenic properties, adhering to bone surfaces and promoting healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If non-absorbable bone wax is used for mechanical hemostasis, then bleeding control is effective, but osteogenesis is inhibited and infection risk increases
Solution Approach 1:
The patent changes the key parameter of absorbability from non-absorbable to absorbable. The bone wax is formulated to be gradually absorbed by the body over time, eliminating the permanent foreign body that causes infection and osteogenesis inhibition, while maintaining effective hemostasis during the critical healing period
Solution Approach 2:
The patent creates a composite material combining absorbable wax components with osteogenic promoters and anti-infective agents. This composite structure allows the material to simultaneously provide mechanical hemostasis, promote bone healing, and prevent infection, resolving the harmful effects of traditional non-absorbable bone wax
2Object-generated harmful factors
If paste-like materials are used for bone defect filling, then osteogenesis is promoted, but adherence to bone surface is unreliable and hemostasis is ineffective
Solution Approach 1:
The patent merges the functions of hemostasis and osteogenesis into a single integrated material. The bone wax formulation combines hemostatic properties with osteogenic promoters, allowing it to simultaneously control bleeding and promote bone healing, unlike separate traditional materials
Solution Approach 2:
The patent changes the physical consistency parameter from soft paste-like to moldable wax. This allows the material to be shaped and pressed into bone defects and bleeding surfaces, providing reliable mechanical adherence and effective tamponade while maintaining osteogenic capability
3Speed
If electrocautery is used for hemostasis, then bleeding is controlled rapidly, but tissue damage occurs and osteogenesis is delayed
Solution Approach 1:
The patent replaces the thermal/electrical system of electrocautery with a mechanical system. The moldable bone wax provides mechanical hemostasis through physical tamponade and pressure, substituting the harmful thermal energy of electrocautery with a cold, non-destructive mechanical approach that achieves hemostasis without tissue damage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions effectively control bleeding, absorb harmlessly, and stimulate bone growth, reducing the risk of infection and enhancing bone healing without causing tissue damage, offering a superior alternative to existing methods.
Implementation Method 1
The compositions of the invention are mechanically hemostatic and in some embodiments, additionally possess osteogenic properties. The putty-like compositions are mechanically hemostatic tamponades with or without demineralized bone matrix (DBM) and with or without an anti-infective agent.
Implementation Method 2
The putty-like compositions of the present invention are mechanically hemostatic tamponades with or without demineralized bone matrix (DBM) and with or without an anti-infective agent. The compositions employed in the novel method of the invention are putty or putty-like in consistency... after which the composition post-operatively is absorbed and harmlessly eliminated from the body.
Implementation Method 3
In addition to being mechanically hemostatic, the compositions are also osteogenic when they contain demineralized bone matrix (DBM) to aid in the induction of bone growth as an added, but optional, ingredient.
Implementation Method 4
The addition of a suitable anti-infective agent such as tobramycin or gentamicin or anti-microbial agents such as iodine, colloidal silver, sulfadiazaine and the like, serves to reduce the potential for infection, particularly in contaminated open wounds such as compound fractures.
Data Source
AI summary
Disclosed are body-implantable, appropriately absorbable, biocompatible, putty-like compositions useful as mechanical hemostatic tamponades for the control of osseous hemorrhage arising from surgical intervention or trauma and for providing an osteoinductive matrix to foster improved bone healing.