Absorbable Bone Wax for Hemostasis and Bone Regeneration
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Traditional bone wax used in surgical procedures is non-absorbable, causing chronic inflammation, foreign body reactions, and inhibiting bone healing due to its non-renewable nature and poor adhesion properties, making it unsuitable for bone regeneration and contaminated areas.
Innovation Solution
A method involving the preparation of absorbable bone wax using polyoxypropylene polyoxyethylene block copolymer, hemostatic starch microspheres, and β-tricalcium phosphate loaded with nanosilver, which enhances biocompatibility, promotes bone repair, and provides antibacterial effects, while also achieving rapid hemostasis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional beeswax-based bone wax is used, then hemostatic effect is achieved, but chronic inflammation and foreign body reactions occur due to non-absorbability
Solution Approach 1:
The patent changes the fundamental parameter of absorbability by replacing traditional beeswax with absorbable polymers (polyglycolic acid, polylactic acid, polycaprolactone) as the base material. This transformation maintains the hemostatic function while enabling the material to be absorbed by the body, thereby eliminating chronic inflammation and foreign body reactions associated with non-absorbable traditional bone wax.
Solution Approach 2:
The patent creates a composite material system combining absorbable polymer base materials with hemostatic agents (such as thrombin, fibrinogen, or collagen). This composite structure integrates the advantages of both components: the absorbable polymer provides biocompatibility and degradation capability, while the hemostatic agents provide effective bleeding control, thus resolving the contradiction between achieving hemostasis and avoiding inflammatory reactions.
2Reliability
If traditional beeswax-based bone wax is used, then hemostasis is achieved, but bone healing is inhibited due to non-renewable nature
Solution Approach 1:
The patent transforms the material from non-renewable to renewable by selecting polymers that can be metabolized and absorbed by the body. The use of polyglycolic acid, polylactic acid, and polycaprolactone ensures that the bone wax will gradually degrade into harmless byproducts that can be eliminated by the body's natural metabolic processes, thereby eliminating the inhibition of bone healing while maintaining effective hemostasis.
Solution Approach 2:
The patent implements a discarding and recovering mechanism where the bone wax material is designed to be temporarily present during surgery for hemostasis, then gradually degraded and absorbed by the body over time. The absorbable polymer matrix breaks down into monomers that can be recovered and utilized by the body's metabolic systems, allowing complete elimination of the foreign material and enabling subsequent bone healing without long-term interference.
3Reliability
If traditional beeswax-based bone wax is used, then bone hemorrhage control is achieved, but adhesion is poor and brittleness is high at room temperature
Solution Approach 1:
The patent changes the physical and chemical parameters of the bone wax material by using synthetic absorbable polymers with different molecular weights and compositions. These polymers can be formulated to have optimal viscosity, adhesion, and flexibility characteristics at room temperature and body temperature, thereby improving both adhesion to bone surfaces and reducing brittleness while maintaining effective hemorrhage control.
Solution Approach 2:
The patent develops composite formulations where absorbable polymer matrices are combined with various additives and modifiers to enhance adhesion properties and reduce brittleness. The composite structure allows optimization of mechanical properties through component selection and ratio adjustment, achieving a balance between hemostatic effectiveness, adhesion strength, and flexibility that overcomes the limitations of traditional beeswax-based formulations.
4Reliability
If traditional beeswax-based bone wax is used, then bone hemorrhage control is achieved, but risk of bone infection increases due to non-absorbability
Solution Approach 1:
The patent changes the absorbability parameter from zero (non-absorbable) to a controlled degradation rate by selecting biodegradable polymers. This transformation allows the bone wax to be temporarily present for hemostasis, then gradually absorbed by the body, eliminating the long-term foreign body that could serve as a nidus for infection while maintaining effective hemorrhage control during the critical postoperative period.
Solution Approach 2:
The patent implements a time-dependent discarding mechanism where the bone wax is designed to fulfill its hemostatic function during surgery and the immediate postoperative period, then gradually degrade and be eliminated by the body's metabolic systems. This temporary presence followed by complete absorption eliminates the long-term infection risk associated with permanent foreign bodies while ensuring adequate hemostatic protection when most needed.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The absorbable bone wax effectively stops bleeding quickly, reduces inflammation, and promotes bone regeneration by providing necessary ionic components and antibacterial properties, making it suitable for bone repair and regeneration.
Implementation Method 1
Starch itself has a certain degree of water absorption, while the micron-sized hemostatic starch microspheres increase the contact area with water, and can quickly absorb water in the blood.
Implementation Method 2
the micron-sized hemostatic starch microspheres play the role of molecular sieve, so that red blood cells, thrombin, platelets, fibrin and other effective components in the blood aggregate on the surfaces of the starch microspheres to form a gel-like mixture so as to achieve the effect of rapid hemostasis
Implementation Method 3
it has a certain solubility in living organism, can release harmless ions to the living organism, participate in metabolism of the living organism, stimulate or induce bone regeneration
Implementation Method 4
Due to its extremely small particles and large surface area, the nanosilver has significant surface effects, quantum size effects and quantum tunneling effects, so that the nanosilver has super activity and permeability, and its bactericidal effect is hundreds of times that of ordinary silver.
Implementation Method 5
the nanosilver has powerful antibacterial and bactericidal effects and broad-spectrum antibacterial activity
Implementation Method 6
Polyoxypropylene polyoxyethylene block copolymer (PEG-PPG-PEG) and polyoxypropylene polyoxyethylene random copolymer (PEG-PPG) are absorbable polymer materials with good hemostatic effects
Data Source
AI summary
Disclosed is absorbable bone wax and a preparation method thereof. The preparation method comprises the steps of: 1) mixing polyoxypropylene polyoxyethylene block copolymer (PEG-PPG-PEG) and polyoxypropylene polyoxyethylene random copolymer (PEG-PPG), and stirring evenly under heating to obtain a liquid mixture; 2) under mechanical stirring and heating condition, adding hemostatic starch microspheres to the liquid mixture obtained in step 1) to obtain a uniformly-mixed liquid; and 3) adding a bone repair material to the uniformly-mixed liquid obtained in step 2), and mixing uniformly to obtain a mixed solution, then pouring the mixed solution into a mold or sub-packaged bottle, and leaving at room temperature for solidifying and shaping to give the absorbable bone wax. The absorbable bone wax of the present invention can achieve the effect of rapid hemostasis, changing the relatively single hemostasis method with traditional bone wax which only depends on physical sealing.