Absorbable Biomedical Composite Material Interfacial Bonding

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Solution Overview

Problem

Current biomedical composite materials made from calcium-phosphorus-containing inorganic salts and biodegradable polyester materials face issues with interfacial compatibility, leading to poor mechanical properties and toughness due to hydrophilicity and uneven distribution of inorganic salts, which restricts their application in bone orthopedics.

Innovation Solution

An absorbable biomedical composite material is developed with a polymer matrix and substrate granules coated with an intermediate layer of random copolymers of lactide, caprolactone, and glycolide, where the intermediate layer has a glass transition temperature not higher than body temperature, enhancing interfacial bonding and mechanical strength while maintaining bioactivity and biocompatibility.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If calcium-phosphorus-containing inorganic salts are blended with absorbable polyester materials, then biocompatibility and bioactivity are improved, but interfacial compatibility deteriorates leading to aggregation and uneven distribution

Engineering Contradiction:

ImprovebiocompatibilityVSAvoidinterfacial compatibility

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent applies an intermediate layer between the inorganic salt granules and the polyester matrix to serve as a mediator. This intermediate layer has compatible properties with both materials, enabling good interfacial bonding while maintaining the biocompatibility and bioactivity benefits of the inorganic salts without their aggregation problems.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates a three-component composite structure consisting of inorganic salt granules, intermediate layer, and polyester matrix. This multi-phase composite design allows each component to contribute its advantageous properties while mitigating the disadvantages of individual material combinations.

Inventive Principle:

Principle #40Composite materials

2Reliability

If inorganic salt granules are added to polyester material, then bioactivity is improved, but toughness deteriorates making the composite material easy to break

Engineering Contradiction:

ImprovebioactivityVSAvoidtoughness

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The intermediate layer acts as a stress-distributing intermediary that prevents stress concentration at the inorganic salt-polyester interface. This eliminates the peeling and cracking problems that would otherwise occur, thereby maintaining toughness while preserving bioactivity.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent modifies the interfacial properties by introducing the intermediate layer, which changes the mechanical parameters at the interface. This prevents stress concentration and crack propagation, thereby improving toughness while maintaining the bioactivity provided by the inorganic salts.

Inventive Principle:

Principle #35Parameter changes

3Strength

If inorganic salts are blended with polyester material, then mechanical strength is improved through reinforcement, but interfacial bonding deteriorates causing peeling and cracks

Engineering Contradiction:

Improvemechanical strengthVSAvoidinterfacial bonding

Core Design Contradiction:

StrengthVSStability of the object's composition

Solution Approach 1:

The intermediate layer serves as a bonding mediator that provides strong adhesion to both the inorganic salt granules and the polyester matrix. This eliminates interfacial peeling and crack formation, allowing the inorganic salts to effectively reinforce the material without interfacial failure.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composite material exhibits improved mechanical strength and toughness, reducing stress concentration and microcracks, and maintaining bioactivity, making it suitable for bone orthopedic applications.

Implementation Method 1

the rubbery intermediate layer can release the concentrated stress caused by the substrate granules and reduce microcracks

Methodology Applied

Scientific EffectStress concentration reduction:

Implementation Method 2

since there is no buffer between the rigid hydroxyapatite granules and the polylactic acids, the toughness of the composite material may be seriously deteriorated

Methodology Applied

Scientific EffectBuffering effect:

Data Source

PatentEP3656406B1Absorbable biomedical composite material and preparation method therefor

Publication Date: 2023.12.27 SHENZHEN CORLIBER SCI

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AI summary

Provided are an absorbable biomedical composite material and a preparation method therefor. The absorbable biomedical composite material comprises: substrate granules containing a calcium-phosphorus compound; an intermediate layer which is coated on the surface of each of the substrate granules and has a first glass transition temperature, the first glass transition temperature being not higher than normal human body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The absorbable biomedical composite material has increased mechanical strength and also improved toughness.