Absorbable Occluder With Staggered Polymer Degradation
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Solution Overview
Problem
Current absorbable polymer occluders made from biodegradable polymers can cause serious inflammatory responses due to the intensive release of degradation products within centralized degradation time periods, leading to potential tissue reactions.
Innovation Solution
The occluder is designed with a woven mesh comprising at least two polymer filaments with different centralized degradation time periods, allowing for controlled degradation and minimizing the release of degradation products, thereby avoiding inflammatory responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If an absorbable polymer occluder is made from biodegradable polymer material, then the long-term complications caused by permanent retention of metal alloy occluder are eliminated, but the polymer can rapidly degrade within a certain time period to release a large number of degradation products that exceed the volume that can be absorbed by the body's tissues, potentially leading to serious inflammatory response
Solution Approach 1:
The polymer occluder is divided into multiple polymer filaments with different degradation rates. This segmentation allows the degradation process to be distributed over time rather than occurring rapidly and simultaneously throughout the entire occluder, thereby preventing the sudden release of large volumes of degradation products that would cause inflammatory response.
Solution Approach 2:
Different regions or filaments of the occluder are made from polymers with different degradation characteristics. This local quality variation ensures that degradation occurs progressively and controllably, with some filaments degrading faster than others, maintaining structural integrity while gradually reducing the occluder mass without overwhelming the body's absorption capacity.
2Duration of action of stationary object
If the woven mesh is formed of a polymer material that degrades rapidly, then the occluder can be absorbed by the body after endothelialization, but the rapid degradation releases a large number of degradation products that exceed the body's absorption capacity, leading to serious inflammatory response
Solution Approach 1:
The occluder structure is segmented into multiple polymer filaments with different degradation time periods. This segmentation transforms the rapid, simultaneous degradation of a single polymer material into a progressive, staggered degradation process, where degradation products are released and absorbed gradually over time, preventing inflammatory response while still achieving complete absorption.
Solution Approach 2:
The degradation time parameter is varied across different polymer filaments. By selecting polymers with different degradation rates, the overall degradation process is extended and distributed over a longer time period, allowing the body's tissues to absorb degradation products at a manageable rate rather than being overwhelmed by rapid degradation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of polymer filaments with varying degradation times prevents the sudden release of large amounts of degradation products, reducing the risk of inflammatory reactions and ensuring a stable frame structure during the implantation period, as demonstrated by in-vitro and in-vivo experiments.
Implementation Method 1
The absorbable polymer occluder can degrade to be absorbed by the body after endothelialization
Data Source
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AI summary
An absorbable occluder (100) comprises a woven mesh (110), wherein the woven mesh (110) comprises at least two polymer filaments with different centralized degradation time periods, or comprises a polymer filament made by blending at least two polymers with different centralized degradation time periods. The absorbable occluder (100) can avoid the tissue inflammatory response caused by the polymer filaments of the woven mesh (110) centralized degrading within the same period.