Absorbable Putty for Bone Hemostasis and Osteogenesis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current bone hemostasis and healing techniques face challenges with non-absorbable bone waxes, electrocautery, and existing absorbable materials that fail to effectively control osseous hemorrhage and promote bone healing due to issues with cohesiveness, biocompatibility, and absorption rates.
Innovation Solution
Development of absorbable putty-like compositions with varying viscosities and cohesive strengths, incorporating finely powdered bulking agents and dispersing vehicles, which provide immediate hemostasis, promote bone healing, and include additives like growth factors, anti-infectives, and radiopaque substances for enhanced osteogenesis and infection control.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If non-absorbable bone waxes are used for hemostasis, then immediate hemostatic effect is achieved, but osteogenesis is inhibited and permanent foreign body remains
Solution Approach 1:
The patent changes the physical and chemical parameters of bone wax by incorporating absorbable polymers (polyglycolide, polylactide, copolymers) to replace or supplement non-absorbable components. This allows the material to maintain hemostatic effectiveness while being gradually absorbed by the body, transforming it from a permanent foreign body to a temporary hemostatic agent that facilitates osteogenesis.
Solution Approach 2:
The invention creates composite materials combining absorbable polymers with traditional bone wax components or other hemostatic agents. These composites provide both immediate hemostatic effect and subsequent absorption capability, resolving the contradiction between effective hemostasis and permanent foreign body presence.
2Duration of action of stationary object
If absorbable materials are used for bone hemostasis, then osteogenesis is promoted, but hemostatic effectiveness is reduced
Solution Approach 1:
The patent optimizes the degradation rate parameters of absorbable polymers to ensure they maintain structural integrity and hemostatic function during the critical initial period, then gradually absorb. This parameter optimization allows absorbable materials to achieve both effective hemostasis and promoted osteogenesis.
3Speed
If electrocautery is used for hemostasis, then rapid bleeding control is achieved, but tissue damage occurs and osteogenesis is delayed
Solution Approach 1:
The patent replaces the thermal/electrical energy-based electrocautery method with a mechanically applicable absorbable putty material that achieves hemostasis through physical placement and gradual absorption. This substitution eliminates thermal tissue damage while maintaining effective bleeding control.
4Duration of action of stationary object
If paste-like materials are used to fill bone defects, then osteogenesis is induced, but adherence to injured bone is poor and hemostasis is ineffective
Solution Approach 1:
The invention creates composite putty materials combining absorbable polymer matrices with particulate bone graft materials or other osteoinductive agents. This composite structure provides both effective adherence to bone surfaces and induced osteogenesis, while maintaining hemostatic capability.
Solution Approach 2:
The patent creates materials with spatially varying properties - the outer surface provides adherence and hemostasis, while the internal structure promotes osteogenesis and controlled absorption. This local quality differentiation resolves the contradiction between adherence effectiveness and osteoinductive capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions offer rapid absorption, improved bone healing, reduced infection risk, and enhanced visibility during surgical procedures, addressing the limitations of existing materials by providing effective mechanical hemostasis and osteoinductive properties.
Implementation Method 1
absorbable formulations
Implementation Method 2
rapid absorption
Data Source
AI summary
Two (or more), -component, body-implantable, absorbable, biocompatible, putty, and non-putty hemostatic tamponades for use in surgery. Component 1 is a finely powdered bulking material, preferably less than 50 microns, e.g. the calcium, magnesium, aluminum, or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms, hydroxyapatite, DBM, polyglycolide, polylactide, polydioxinones, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. Component 2, a dispersing vehicle, may be esters of C8-C18 monohydric alcohols with C2-C6 aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with C2-C10 aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; alkyl aryl ethers and ketones, polyhydroxy compounds and esters and ethers thereof; (ethylene oxide/propylene oxide copolymers), oils e.g. olive oil, castor oil and triglycerides.