ABTT Transdermal Drug Delivery System
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Solution Overview
Problem
Current drug administration methods, including subcutaneous, oral, intramuscular, intravenous, and transdermal delivery, face challenges such as inefficiency, side effects, pain, and the need for large doses due to the blood-brain barrier and skin permeability issues, particularly when targeting the brain.
Innovation Solution
A non-invasive transdermal delivery system utilizing the Abreu brain thermal tunnel (ABTT) for direct drug administration to the brain, employing adhesive interfaces with pores or reservoirs, pressure mechanisms, and adjustable arms to ensure precise drug delivery to the ABTT skin and associated veins, minimizing side effects and dosage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional transdermal delivery methods are used, then non-invasive drug administration is achieved, but the skin barrier limits drug penetration and requires large doses
Solution Approach 1:
The patent identifies the ABTT terminus as a unique location with specialized properties (thin skin, high vascularity, direct brain connection) that differs from conventional transdermal sites. This local quality allows enhanced drug penetration while maintaining non-invasive administration, resolving the contradiction between ease of operation and penetration reliability.
Solution Approach 2:
The ABTT thermal tunnel acts as an intermediary pathway between the skin and brain. By utilizing this natural thermal and vascular conduit, the system enables drugs to bypass the blood-brain barrier without invasive injection, achieving both non-invasive administration and reliable brain targeting.
2Productivity
If drugs are administered remotely from the brain, then systemic circulation is achieved, but the blood-brain barrier reduces drug effectiveness
Solution Approach 1:
The system segments the drug delivery pathway into two phases: (1) transdermal absorption at the ABTT terminus, and (2) direct transport through the thermal tunnel to the brain. This segmentation allows drugs to enter the system non-invasively while ensuring direct brain targeting, overcoming the blood-brain barrier limitation.
Solution Approach 2:
The patent replaces the mechanical injection system with a thermal field-based delivery mechanism. The ABTT thermal tunnel utilizes thermal energy and vascular flow to transport drugs directly to the brain, substituting the need for mechanical needles and invasive procedures while maintaining effective brain delivery.
3Reliability
If large doses are used to overcome the blood-brain barrier, then brain drug concentration is achieved, but side effects increase
Solution Approach 1:
By targeting the ABTT terminus with its unique properties (thin skin, high vascularity, direct brain connection), the system achieves concentrated brain delivery with minimal systemic distribution. This local quality enables effective brain drug concentration without the need for large doses, thereby reducing side effects.
Solution Approach 2:
The patent converts the natural thermal and vascular properties of the ABTT terminus into a beneficial delivery mechanism. The thermal tunnel, which naturally facilitates heat and fluid flow, is harnessed to transport drugs directly to the brain, turning a physiological feature into an advantage for targeted delivery and reducing harmful side effects.
4Reliability
If adhesive interfaces with pores are used, then direct skin contact is achieved, but device complexity increases
Solution Approach 1:
The adhesive interface incorporates porous structures that facilitate direct skin contact and drug penetration while maintaining device integrity. The porosity allows the adhesive to conform to the skin surface and enable controlled drug release, achieving precise delivery without excessive complexity.
Solution Approach 2:
The patent employs flexible adhesive layers and thin film structures that can conform to the skin surface at the ABTT terminus. These flexible components ensure direct skin contact and proper drug delivery while keeping the device structure simple and manageable.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The ABTT-based system allows for targeted, efficient drug delivery to the brain with reduced doses, minimizing side effects and eliminating the need for invasive methods by leveraging the unique properties of the ABTT skin for direct drug transport to the brain.
Implementation Method 1
The structure of transdermal delivery patches generally comprises an outer layer, a middle layer that contains the drug, and a liner and/or a release liner that protects the adhesive layer
Implementation Method 2
The transdermal flux of a drug depends on the diffusion coefficient of the drug; the thickness of the epidermis and dermis, and the condition of the skin at the application site
Implementation Method 3
a reservoir housing an absorbent material such as a sponge, a pad, a gel, and the like, said absorbent material being soaked with a solution of a medication
Implementation Method 4
an absorbent material such as a sponge, a pad, a gel, and the like, said absorbent material being soaked with a solution of a medication
Implementation Method 5
pressure mechanisms, and adjustable arms to ensure precise drug delivery to the ABTT skin
Data Source
AI summary
Provided are devices for therapeutic interaction with an Abreu brain thermal tunnel (ABTT) terminus. Such devices are configured to provide one or more drugs to an ABTT terminus, and may provide heat to or remove heat from the ABTT terminus while providing the one or more drugs.