A.C.C. Herbal Extract Inhibits Nitric Oxide and Cytokines

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Solution Overview

Problem

Current treatments for inflammatory responses lack effective anti-inflammatory and antibacterial agents, particularly for conditions like chronic inflammation, rheumatoid arthritis, and skin irritations such as diaper rash and heat rash, which are exacerbated by excessive nitric oxide production and inflammatory cytokines.

Innovation Solution

A distillation-extracted combination of 14 herbal medicines, including Phellodendron bark, Scutellaria baicalensis, and others, forms an A.C.C. extract that inhibits nitric oxide and inflammatory cytokine production while exhibiting strong antibacterial effects against various pathogens.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If iNOS is stimulated by interferon-γ, inflammatory cytokines, and LPS to produce nitric oxide for antibacterial activity and tumor removal, then antibacterial and anti-tumor effects are improved, but vascular permeability increases, edema occurs, and inflammatory response is exacerbated

Engineering Contradiction:

Improveantibacterial activityVSAvoidinflammatory response

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent uses natural product extracts as intermediary substances that selectively modulate iNOS activity and inflammatory cytokine production. These extracts contain multiple bioactive compounds that work synergistically to inhibit excessive NO production while preserving antibacterial defense mechanisms, thereby mediating between the beneficial antibacterial effect and the harmful inflammatory response

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent employs natural product extracts to change the parameters of inflammatory response by modulating the expression levels of iNOS and inflammatory cytokines. The extracts alter the concentration and activity of key mediators (NO, TNF-α, IL-6, IL-1β) to achieve a therapeutic window where antibacterial activity is maintained while inflammatory damage is reduced

Inventive Principle:

Principle #35Parameter changes

2Reliability

If LPS stimulates macrophages to secrete inflammatory cytokines TNF-α, IL-1β, and IL-6 for immune response, then pathogen defense is improved, but synthesis of inflammatory mediators increases causing vascular permeability, edema, and tissue damage

Engineering Contradiction:

Improveimmune responseVSAvoidtissue damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent converts the harmful excessive inflammatory response into a beneficial controlled immune reaction. By using natural product extracts, the system redirects the inflammatory pathway to produce protective immunity while minimizing tissue damage, effectively transforming the double-edged sword of inflammation into a controlled defense mechanism

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent utilizes composite natural product extracts containing multiple phytochemicals from different plant sources. These composite extracts work synergistically to modulate the LPS-induced inflammatory cascade, with different compounds targeting various stages of cytokine production and signaling pathways to achieve comprehensive anti-inflammatory protection

Inventive Principle:

Principle #40Composite materials

3Reliability

If natural product extracts with anti-bacterial and anti-inflammatory activities are developed, then therapeutic efficacy is improved, but complexity of extract composition and standardization difficulty increase

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidextract composition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent develops natural product extracts that exhibit multiple therapeutic functions simultaneously - antibacterial, anti-inflammatory, and anti-edematous activities. This multi-functionality is achieved by combining compounds from multiple plant sources that target different pathways involved in inflammatory and infectious processes, providing broad-spectrum therapeutic coverage

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS11590191B2A.C.C. extract having anti-inflammatory and antimicrobial effect and composition comprising same as active ingredient

Publication Date: 2023.02.28 NATURE FOUR

AI summary

Provided is an A.C.C. extract from a combination of medicinal herbs, which are Phellodendron bark, Scutellaria baicalensis, Paeonia lactiflora Pall, Dictamnus dasycarpus Turcz, Anemarrhena asphodeloides, Alumen, Dryobalanops aromatica Gaertner, Mentha arvensis var. piperascens, Inula helenium, Syringa velutina var. kamibayashii, Corydalis incisa, Eclipta prostrata, Lonicera japonica, and Glycyrrhiza uralensis, and a composition having the same as an active ingredient. The A.C.C. extract of the present invention reduces production of TNF-α IL-1β and IL-6, thereby regulating the expression of iNOS and thus exhibiting an anti-inflammatory effect inhibiting NO production. Also clinically, the A.C.C. extract of the present invention is a substance that alleviates symptoms such as diaper rash and miliaria through anti-inflammatory and antimicrobial activitities and can be used as an effective anti-inflammatory agent.