Aceclidine Ophthalmic Drops for Dynamic Presbyopia Correction

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Solution Overview

Problem

Presbyopia, a refractive error causing close objects to appear out of focus with aging, affects a significant portion of the population and current treatments like eyeglasses or surgery have limitations.

Innovation Solution

Administering a miotic agent, such as aceclidine or its salt, in the form of ophthalmic drops to the eye, optionally with a second drop 2 minutes later, to improve vision by reducing pupil size and enhancing focus, suitable for individuals with or without ocular surgery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Use of energy by moving object

If corrective eyeglasses or contact lenses are used to treat presbyopia, then near vision is improved, but distance vision may be compromised or require additional corrective measures

Engineering Contradiction:

Improvenear vision capabilityVSAvoidvision correction versatility

Core Design Contradiction:

Use of energy by moving objectVSAdaptability or versatility

Solution Approach 1:

The patent employs dynamic pupil size adjustment through miotic agents that can be administered topically. The miotic agents cause pupillary constriction which dynamically changes the optical properties of the eye, allowing a single lens to provide both near and distance vision correction by controlling the effective aperture size rather than requiring multiple fixed corrective lenses

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The invention changes the physical parameter of pupil size through pharmacological action. By administering miotic agents that constrict the pupil, the system modifies the effective aperture diameter to optimize optical performance for different viewing distances, thereby resolving the contradiction between near vision correction and distance vision capability

Inventive Principle:

Principle #35Parameter changes

2Use of energy by moving object

If refractive surgery is performed to correct presbyopia, then vision is improved, but the procedure has limitations and may not be suitable for all patients

Engineering Contradiction:

Improvevision qualityVSAvoidpatient suitability

Core Design Contradiction:

Use of energy by moving objectVSAdaptability or versatility

Solution Approach 1:

The patent replaces mechanical surgical intervention with a pharmacological system. Instead of performing refractive surgery to permanently alter the eye's optical structure, the invention uses topically administered miotic agents that temporarily and reversibly constrict the pupil to provide the desired optical correction, thereby avoiding surgical limitations and expanding patient suitability

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The miotic agent system provides self-service vision correction through topical administration. The patient applies the medication as needed, and the body's own physiological response (pupillary constriction) provides the corrective effect without requiring external surgical intervention or complex optical devices

Inventive Principle:

Principle #25Self-service

3Use of energy by moving object

If miotic agents are administered to reduce pupil size for vision improvement, then near and distance vision are enhanced, but the duration of action is limited

Engineering Contradiction:

Improvevision clarityVSAvoideffect duration

Core Design Contradiction:

Use of energy by moving objectVSDuration of action of moving object

Solution Approach 1:

The patent implements continuous vision correction by administering miotic agents multiple times throughout the day. The dosing regimen is designed to maintain adequate pupillary constriction and optical performance continuously, ensuring that the useful action of vision improvement persists throughout the desired period without significant interruption

Inventive Principle:

Principle #20Continuity of useful action

4Ease of operation

If ophthalmic compositions are stored at room temperature, then accessibility is improved, but composition stability deteriorates over time

Engineering Contradiction:

Improvestorage accessibilityVSAvoidcomposition stability

Core Design Contradiction:

Ease of operationVSStability of the object's composition

Solution Approach 1:

The invention modifies the chemical parameters of the ophthalmic composition by adjusting pH to acidic levels (below 6.0) and incorporating specific stabilizing agents. These parameter changes enhance the chemical stability of the miotic agent at room temperature, preventing degradation and maintaining composition integrity during storage without requiring refrigeration

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method provides improved near and distance vision for up to 10 hours with reduced pupil size, potentially reducing the need for corrective lenses and maintaining efficacy for extended storage periods under various temperature conditions.

Implementation Method 1

a miotic (e.g., aceclidine or a salt thereof)... reducing pupil size and enhancing focus

Methodology Applied

Scientific EffectPupil constriction (miotic effect):

Data Source

PatentUS20250288566A1Compositions, methods, and systems in treating presbyopia

Publication Date: 2025.09.18 LENZ THERAPEUTICS OPERATIONS INC

AI summary

The present disclosure provides methods comprising administration protocols of an ophthalmological composition, such as comprising aceclidine.