Aceclidine Eye Drops for Reversible Presbyopia Correction
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Solution Overview
Problem
Presbyopia, a refractive error causing close objects to appear out of focus with aging, affects a significant portion of the population, and current treatments like eyeglasses, contact lenses, and surgery have limitations.
Innovation Solution
Administering a composition containing aceclidine or its salt to the eye, typically in two drops spaced 2 minutes apart, to improve near and distance vision, with the option to store the composition at various temperatures for extended periods without preservatives.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If corrective eyeglasses or contact lenses are used to treat presbyopia, then near vision is improved, but the need for additional corrective devices increases and does not address the underlying aging-related optical change
Solution Approach 1:
The patent applies dynamics by using a reversible pharmacological mechanism (miotic agent) that temporarily restores ciliary muscle function to improve near vision, rather than requiring permanent corrective devices. The effect is transient and reversible, allowing the eye to dynamically adjust focus without relying on external lenses.
Solution Approach 2:
The patent changes the physiological parameter of ciliary muscle tone by administering a miotic agent that increases muscle contraction, thereby improving the eye's ability to focus on near objects. This parameter change provides temporary vision improvement without requiring permanent corrective devices.
2Measurement precision
If refractive surgery is performed to correct presbyopia, then vision is improved, but the procedure carries surgical risks and is not reversible
Solution Approach 1:
The patent uses a temporary, reversible pharmacological intervention rather than permanent surgical modification. The miotic agent provides vision improvement temporarily and can be discontinued without permanent changes to the eye, eliminating surgical risks while maintaining the option for repeated treatment.
Solution Approach 2:
Instead of permanently altering the eye's optical structure through surgery, the patent temporarily reverses the age-related relaxation of the ciliary muscle through pharmacological stimulation, achieving vision improvement without permanent structural changes.
3Measurement precision
If lens implants are used to treat presbyopia, then near and distance vision are improved, but the procedure is invasive and requires permanent implantation
Solution Approach 1:
The patent employs a temporary, non-invasive pharmacological treatment that can be administered multiple times without permanent implantation. The miotic agent provides vision improvement temporarily and can be discontinued, avoiding the invasive nature of lens implants.
Solution Approach 2:
The patent enables the eye's own ciliary muscle to function more effectively through pharmacological stimulation, allowing the body to self-correct the presbyopic condition temporarily without requiring external implants or surgical intervention.
4Ease of manufacture
If aceclidine composition is stored at room temperature, then shipping and storage are simplified, but the composition may degrade over time
Solution Approach 1:
The patent changes the storage temperature parameter from refrigerated to room temperature, simplifying shipping and storage requirements. The formulation is specifically designed to maintain stability under room temperature conditions, allowing the composition to be stored and shipped without special temperature control.
Solution Approach 2:
The patent converts the potential harm of room temperature degradation into a benefit by formulating the composition specifically to be stable under room temperature conditions. This allows simplified storage and shipping while maintaining composition integrity, turning a potential weakness into a strength.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances visual acuity for presbyopic individuals by improving near vision by 3-6 lines and distance vision by 1-3 letters, reducing the need for corrective lenses, and allowing for stable composition storage and shipping.
Implementation Method 1
aceclidine is a miotic agent that constricts the pupil
Implementation Method 2
aceclidine has been used to treat glaucoma and to improve the depth of field of the eye
Data Source
AI summary
The present disclosure provides methods comprising administration protocols of an ophthalmological composition, such as comprising aceclidine.