Aceclidine Eye Drops for Presbyopia Without Corrective Lenses
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Solution Overview
Problem
Presbyopia, a refractive error causing close objects to appear out of focus with aging, affects a significant portion of the population, and current treatments like eyeglasses, contact lenses, and surgery have limitations.
Innovation Solution
Administering a composition containing aceclidine or its salt to the eye, typically in two drops spaced 2 minutes apart, to improve near and distance vision, with potential concomitant benefits for myopia, and reduce the need for corrective lenses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If corrective eyeglasses or contact lenses are used to treat presbyopia, then near vision is improved, but the need for additional corrective devices increases and does not address the underlying aging-related optical changes
Solution Approach 1:
The patent applies parameter changes by using aceclidine, a miotic agent that alters the physiological parameters of the eye by constricting the pupil and stimulating the ciliary muscle. This pharmacological approach changes the optical parameters of the eye temporarily, allowing near vision improvement without requiring permanent corrective devices. The composition modifies the eye's refractive state through chemical action rather than mechanical correction.
Solution Approach 2:
The patent replaces the mechanical system of corrective lenses with a pharmacological system. Instead of using external lenses to optically correct vision, the invention uses aceclidine to directly affect the eye's internal mechanics - specifically the ciliary muscle and pupil size - to achieve the same visual improvement. This substitution eliminates the need for continuous wear of corrective devices.
2Measurement precision
If refractive surgery is performed to correct presbyopia, then vision is improved, but the procedure carries surgical risks and requires recovery time
Solution Approach 1:
The patent substitutes the mechanical/surgical intervention with a pharmacological one. Instead of performing refractive surgery to permanently change the eye's curvature, the invention uses aceclidine to temporarily modify the eye's optical properties through pupil constriction and ciliary muscle stimulation. This replacement eliminates all surgical risks while achieving the desired vision improvement.
Solution Approach 2:
The patent employs a temporary, reversible pharmacological solution rather than a permanent surgical modification. The aceclidine composition provides vision improvement during its active period (typically 4-6 hours) and then wears off, allowing the eye to return to its baseline state. This approach treats the condition symptomatically and temporarily, avoiding the irreversible changes and risks of surgery.
3Measurement precision
If lens implants are used to treat presbyopia, then near and distance vision are improved, but the procedure is invasive and requires surgical intervention
Solution Approach 1:
The patent replaces the invasive mechanical implantation with a non-invasive pharmacological treatment. Instead of surgically inserting lens implants to change the eye's refractive power, the invention uses aceclidine to temporarily achieve the same optical effect through chemical action on the pupil and ciliary muscle. This substitution completely avoids surgical intervention while maintaining the ability to improve both near and distance vision during the drug's active period.
4Ease of operation
If aceclidine composition is stored at room temperature, then accessibility is improved, but the composition stability may be compromised over extended periods
Solution Approach 1:
The patent applies parameter changes by formulating the aceclidine composition with specific stabilizing agents and adjusting the pH level to optimize both stability and efficacy. The composition includes buffering agents and preservatives that maintain the chemical integrity of aceclidine at room temperature. By carefully controlling the formulation parameters, the patent enables room temperature storage without significant degradation, making the product more accessible while maintaining stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method provides improved near vision by 3-6 lines and distance vision by 1-3 letters, reducing dependence on corrective lenses for at least 10 hours, with stable aceclidine compositions maintaining efficacy for up to 12 months at various temperatures.
Implementation Method 1
a composition comprising a miotic (e.g., aceclidine or a salt thereof)
Implementation Method 2
improve near vision by 3-6 lines and distance vision by 1-3 letters
Data Source
AI summary
The present disclosure provides methods comprising administration protocols of an ophthalmological composition, such as comprising aceclidine.