Acellular Matrix Glue Reinforcement Bonding
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional methods for combining synthetic constructs with acellular matrix face issues such as delamination and cumbersome processing techniques, leading to poor handling properties.
Innovation Solution
A novel acellular matrix glue is created by mixing decellularized tissue in an aqueous solution and incubating it at a suitable temperature, which is then used to form a reinforced acellular matrix with a textile reinforcement layer, enhancing integration and flexibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods are used to combine synthetic constructs with acellular matrix, then the combination can be achieved, but delamination occurs and handling properties are poor
Solution Approach 1:
The patent introduces an acellular matrix glue as an intermediary substance that facilitates bonding between synthetic constructs and acellular matrix. This glue acts as a mediator layer that prevents direct contact between the synthetic construct and acellular matrix, thereby preventing delamination while improving handling properties through enhanced bonding strength and flexibility.
2Reliability
If conventional methods are used to combine synthetic constructs with acellular matrix, then the combination can be achieved, but processing techniques become cumbersome
Solution Approach 1:
The patent merges the acellular matrix glue with the acellular matrix and synthetic construct into a single integrated assembly process. The glue is applied to the acellular matrix, and the synthetic construct is then attached to the glued surface, creating a unified structure that simplifies processing compared to separate conventional methods while maintaining combination stability.
3Reliability
If acellular matrix glue is used to bind layers, then delamination is prevented and handling properties are improved, but the process requires incubation at specific temperatures
Solution Approach 1:
The patent utilizes parameter changes in temperature to control the bonding process. The acellular matrix glue is incubated at specific temperatures (e.g., 37°C to 42°C) to activate bonding between layers. This temperature-controlled process ensures reliable layer bonding while managing the thermal parameters to achieve optimal bonding strength without excessive heat exposure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The acellular matrix glue effectively binds the acellular matrix and reinforcement layers, preventing delamination and improving handling properties, while allowing for the incorporation of bioactive agents for enhanced tissue repair and engineering applications.
Implementation Method 1
The acellular matrix glue effectively binds the acellular matrix and reinforcement layers, preventing delamination
Implementation Method 2
The mixture is incubated in a sufficient temperature range for a sufficient time to effectively form an acellular matrix glue
Data Source
AI summary
An acellular matrix glue and a method of making is disclosed. Specifically, an acellular matrix glue that is useful in preparing a reinforced acellular matrix for medical applications including tissue engineering and hernia repair.