Flowable Acellular Tissue Matrix for Long-Lasting Injection
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Solution Overview
Problem
Current injectable materials for tissue treatment, such as hyaluronic-acid-based materials, provide only temporary improvements due to eventual resorption by the body, necessitating a need for longer-lasting tissue product compositions suitable for injection.
Innovation Solution
Development of tissue product compositions comprising acellular tissue matrix particles mixed within a flowable carrier comprising a hyaluronic acid based material, which can be easily handled and injected, providing a scaffold for tissue regeneration and potentially longer-lasting effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If hyaluronic-acid-based materials are used for tissue treatment, then injectability and ease of application are improved, but duration of action deteriorates due to eventual resorption by the body
Solution Approach 1:
The patent combines acellular tissue matrix particles with hyaluronic acid carrier to create a composite injectable material. The acellular tissue matrix provides long-lasting structural support and tissue regeneration capability, while the hyaluronic acid carrier ensures ease of injection and initial flowability. This composite structure resolves the contradiction by integrating materials with complementary properties - the durable acellular matrix extends duration of action while the hyaluronic acid maintains injectability.
2Duration of action of moving object
If acellular tissue matrix particles are mixed within a flowable carrier, then duration of action is improved through longer-lasting tissue regeneration, but device complexity increases due to mixing and handling requirements
Solution Approach 1:
The patent merges the acellular tissue matrix particles with the flowable hyaluronic acid carrier into a single integrated composition that can be loaded into standard injection devices. This combining eliminates the need for separate components or complex assembly procedures, allowing the durable acellular matrix to be delivered through conventional injection equipment without increasing device complexity.
Solution Approach 2:
The hyaluronic acid carrier acts as an intermediary substance that facilitates the injection of acellular tissue matrix particles through standard needles and syringes. The carrier provides the necessary flowability for easy injection while carrying the particulate acellular matrix to the target site, where it then provides long-lasting tissue regeneration effects without requiring specialized delivery devices.
Data Source
AI summary
Tissue product compositions and methods for treating a patient are provided. The tissue product composition may include a flowable carrier including a hyaluronic acid based material and acellular tissue matrix particles mixed within the carrier. Methods of producing the tissue product composition and an injection device filled with the tissue product composition are also provided.