Acellular Tissue Matrix Mesh for Regeneration
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Solution Overview
Problem
Current methods for tissue repair often fail to provide optimal conditions for cellular regeneration and are prone to infection and adhesion, limiting their effectiveness in repairing damaged or defective tissues.
Innovation Solution
A biocompatible tissue repair composition is created by incubating acellular tissue matrix fragments in an acidic solution, then applying and drying them onto a mesh substrate, which minimizes irreversible collagen denaturation and promotes a favorable environment for tissue regeneration without significant inflammatory response.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current methods are used for tissue repair, then tissue regeneration can occur, but the likelihood of infection and adhesion increases
Solution Approach 1:
The patent extracts and removes harmful elements (bacteria, debris, damaged tissue) from the wound site through the action of specialized cells during the inflammatory phase, creating a cleaner environment for regeneration while reducing infection risk
Solution Approach 2:
The patent prepares the wound site in advance by establishing the inflammatory phase first, which clears debris and damaged tissue before cellular regeneration begins, thereby preventing infection and adhesion during the subsequent regeneration process
2Reliability
If tissue repair methods are applied, then damaged tissue can be repaired, but optimal conditions for cellular regeneration are not provided
Solution Approach 1:
The patent modifies physical and chemical parameters of the wound environment including pH levels, oxygen tension, and growth factor concentrations to create optimal conditions that stimulate cellular regeneration while maintaining tissue repair effectiveness
Solution Approach 2:
The patent introduces intermediary substances such as growth factors, cytokines, and extracellular matrix components that mediate between the damaged tissue and regenerating cells, providing the necessary signals and support for optimal cellular regeneration
3Reliability
If acellular tissue matrix is used, then biocompatibility is improved, but the process complexity increases due to acid treatment and drying steps
Solution Approach 1:
The patent applies controlled acid treatment to swell the acellular tissue matrix fragments and then uses drying processes to create a stable, biocompatible product. These parameter changes (pH, moisture content) transform the raw material into a clinically useful form with improved biocompatibility
Solution Approach 2:
The patent performs acid treatment and drying as preliminary processing steps before clinical application. This advance preparation creates a stable, biocompatible product that is ready for implantation, reducing complexity during the actual surgical procedure
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively supports tissue regeneration by reducing adhesions and infection risk, providing a biocompatible mesh that facilitates cellular activity and tissue repair while maintaining structural integrity.
Implementation Method 1
incubating a plurality of fragments of an acellular tissue matrix (ATM) in an acidic solution to create a homogeneous suspension of swollen ATM fragments, wherein the acidic solution has a pH less than 3.0 and does not cause substantial irreversible denaturation of collagen fibers in the ATM
Implementation Method 2
drying the coated substrate to form a mesh composition
Data Source
AI summary
The invention provides tissue repair compositions and methods of making the tissue repair compositions. Also featured are methods of treatment using the tissue repair compositions and articles of manufacture that include the tissue repair compositions.