Acetic Acid-Acetate Buffer Dialysis Agent for Corrosion and Odor Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current dialysis agents face challenges in maintaining stable glucose storage, reducing acetic acid odor, and preventing corrosion of dialysate delivery systems and machines, particularly due to high acetate ion content and the use of citric acid, which affects ionized calcium levels and patient safety.
Innovation Solution
A two-pack dialysis agent system with a dialysis agent A containing glucose, acetic acid, and acetate salt at a molar ratio of 1:0.5 to 2, and a dialysis agent B with sodium hydrogen carbonate, allowing for a total acetate ion concentration of 2 to less than 5 mEq/L, thereby reducing acetic acid odor and suppressing corrosion while maintaining glucose stability and ionized calcium levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high concentration of acetic acid is used to adjust pH in dialysis agent, then acid-base balance correction is improved, but acetic acid odor increases and corrosion of dialysate delivery system occurs
Solution Approach 1:
The patent changes the chemical composition parameters by introducing acetate salt (sodium acetate, potassium acetate, etc.) alongside acetic acid to create a buffer system. This allows pH adjustment while controlling free acetic acid concentration, thereby reducing odor and corrosion while maintaining acid-base balance correction capability.
Solution Approach 2:
The patent uses a composite buffer system combining weak acid (acetic acid) and its conjugate base (acetate salt) to achieve pH control. This composite approach provides better buffering capacity and reduces the harmful effects of strong acids while maintaining effective pH adjustment for acid-base balance correction.
2Object-affected harmful factors
If citric acid is used as pH adjusting agent to reduce acetic acid content, then acetic acid-related side effects are reduced, but ionized calcium concentration decreases due to chelation
Solution Approach 1:
The patent changes the pH adjusting agent from citric acid (strong chelator) to an acetic acid-acetate buffer system with controlled parameters. By carefully adjusting the acetic acid and acetate salt concentrations and their molar ratio, the patent achieves pH control while minimizing calcium chelation and maintaining ionized calcium concentration within therapeutic ranges.
3Quantity of substance
If glucose is stored in dialysis agent for extended periods, then nutritional support is improved, but glucose degradation occurs due to acid-catalyzed breakdown
Solution Approach 1:
The patent optimizes the pH and buffer composition parameters to create a stable environment for glucose storage. The acetic acid-acetate buffer system at controlled concentrations and molar ratios provides pH stability that prevents acid-catalyzed glucose degradation, enabling extended storage while maintaining glucose integrity and nutritional support capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively suppresses symptoms like hypotension, improves safety, and enhances the stability and handling of dialysate components, reducing acetic acid odor and corrosion risks, thus improving the quality and safety of dialysis treatments.
Implementation Method 1
dialysis agent A containing glucose, acetic acid and acetate salt wherein the molar ratio of acetic acid:acetate salt is 1:0.5 to 2
Implementation Method 2
bicarbonate hemodialysate having a total acetate ions between 2 and less than 5 mEq/L
Implementation Method 3
dialysis agent B containing sodium hydrogen carbonate
Data Source
AI summary
The purpose of the present invention is to provide a dialysis agent A, which is able to set the total acetate ion content in the dialysate to a low value, excellent in storage stability of glucose, able to reduce the acetic acid odor, and able to suppress the corrosion of the dialysate delivery system and the dialysis machine, as well as to provide a two pack type dialysis agent utilizing the dialysis agent A. In the dialysis agent A used in the preparation of a bicarbonate dialysate, which is used as one part of a two pack type dialysis agent, it becomes possible to prepare a bicarbonate dialysate having the total acetate ion concentration of between 2 mEq/L or more and less than 6 mEq/L by allowing to include glucose, acetic acid and acetate salt and to satisfy the molar ratio of 1:0.5 to 2 of acetic acid and acetate salt. Moreover, according to the dialysis agent A, in addition to the excellent stability of glucose, it is possible to reduce the acetic acid odor, and furthermore possible to suppress the corrosion of the dialysate delivery system and the dialysis machine.