Acetylcholine-Producing Microorganisms for Intestinal Disease Treatment
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Solution Overview
Problem
Current methods fail to reliably stimulate the enteric nervous system to effectively regulate intestinal bowel movements and secretory functions, which is crucial for managing intestinal diseases such as irritable bowel syndrome (IBS) and other disorders associated with impaired intestinal motility and secretion.
Innovation Solution
The use of acetylcholine-producing microorganisms, particularly Lactobacillus strains, to modulate intestinal function by targeting dual stimulation of motility and secretion, offering a promising alternative or addition to existing therapies for chronic IBS and other intestinal disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods are used to stimulate the enteric nervous system, then intestinal motility and secretion can be regulated, but the methods fail to reliably achieve effective stimulation
Solution Approach 1:
The patent uses acetylcholine-producing microorganisms as intermediary substances that reliably stimulate the enteric nervous system. These microorganisms produce acetylcholine, a neurotransmitter that effectively regulates both motility and secretion functions, thereby resolving the contradiction between reliable stimulation and effective regulation.
Solution Approach 2:
The patent changes the biochemical parameter by introducing acetylcholine production capability through specific microorganisms. This parameter change enables reliable and effective stimulation of the enteric nervous system, transforming the unreliable conventional methods into an effective therapeutic approach.
2Reliability
If acetylcholine-producing microorganisms are used, then intestinal health is improved and symptoms are alleviated, but the mechanism is complex
Solution Approach 1:
The acetylcholine-producing microorganisms utilize their own metabolic capabilities to produce acetylcholine directly in the intestinal environment. This self-service mechanism simplifies the treatment approach by eliminating the need for external acetylcholine administration systems, thereby improving treatment effectiveness while reducing mechanistic complexity.
Solution Approach 2:
The patent replaces complex mechanical or pharmacological stimulation systems with a biological mechanism using microorganisms. The microorganisms naturally produce and release acetylcholine, substituting complex external stimulation mechanisms with a simpler biological process that achieves the same therapeutic effect.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The acetylcholine-producing microorganisms effectively improve intestinal health by promoting beneficial gut flora, reducing the risk of intestinal diseases, and alleviating symptoms of IBS and inflammatory bowel diseases by inhibiting pro-inflammatory chemokine IP-10 secretion.
Implementation Method 1
acetylcholine-producing microorganisms, particularly Lactobacillus strains, to modulate intestinal function
Data Source
AI summary
The invention relates to acetylcholine-producing microorganisms for use in the prevention and/or treatment of intestinal diseases, and/or reduction of risks of intestinal diseases, and/or improvement of intestinal health as well as promoting healthy gut flora. The acetylcholine-producing microorganisms may be provided as a pharmaceutical dosage form or as additive to functional food or food supplemental products. Also encompassed is a method for the production of acetylcholine by use of Lactobacilli. Further the invention refers to microbially produced acetylcholine for use in the treatment and/or prevention of intestinal diseases.