Acid and Plant Extract Mixture to Restore Antibiotic Efficacy

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Solution Overview

Problem

Bacterial resistance to antibiotics poses a significant threat to global health, leading to increased mortality and economic losses, necessitating a solution to restore antibiotic efficacy by suppressing pathogenic microorganisms' defense mechanisms.

Innovation Solution

A nutritional and/or pharmacological mixture comprising organic or inorganic acids, essential oils, fatty acids, and plant extracts with bacteriostatic and bactericidal properties, combined with carrier substances, to inhibit bacterial defenses and quorum sensing, enhancing antibiotic effectiveness.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If antibiotics are used to treat bacterial infections, then infection treatment effectiveness is improved, but bacterial resistance to antibiotics develops

Engineering Contradiction:

Improveantibiotic effectivenessVSAvoidbacterial resistance

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent uses bacteriostatic substances that inhibit bacterial growth and quorum sensing mechanisms, converting the harmful bacterial resistance problem into a beneficial solution by restoring antibiotic effectiveness through suppressing bacterial defense mechanisms

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The invention combines multiple substances including organic acids, essential oils, fatty acids, and plant extracts in a composite mixture that synergistically enhances bacteriostatic activity and restores antibiotic efficacy against resistant bacteria

Inventive Principle:

Principle #40Composite materials

2Reliability

If bacterial defense mechanisms are suppressed, then antibiotic efficacy is restored, but complex mixture composition is required

Engineering Contradiction:

Improveantibiotic efficacyVSAvoidmixture composition

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges multiple bacteriostatic substances (organic acids, essential oils, fatty acids, plant extracts) into a single composite mixture that works synergistically to suppress bacterial defenses and restore antibiotic efficacy

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The mixture composition serves multiple functions simultaneously: inhibiting bacterial growth, suppressing quorum sensing, and restoring antibiotic sensitivity, making it a multi-functional solution to bacterial resistance

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The mixture effectively reduces bacterial resistance, allowing antibiotics to regain potency by inhibiting bacterial defenses and biofilm formation, thereby reducing treatment duration and antibiotic consumption.

Implementation Method 1

at least one organic or inorganic acid with bactericidal and/or bacteriostatic properties

Methodology Applied

Scientific EffectBactericidal and bacteriostatic activity:

Implementation Method 2

at least one essential oil with anti-inflammatory and antioxidant properties

Methodology Applied

Scientific EffectAnti-inflammatory activity:

Implementation Method 3

at least one essential oil with anti-inflammatory and antioxidant properties

Methodology Applied

Scientific EffectAntioxidant activity:

Implementation Method 4

at least one fatty acid

Methodology Applied

Scientific EffectBacteriostatic activity:

Implementation Method 5

at least one plant extract

Methodology Applied

Scientific EffectAntimicrobial activity:

Data Source

PatentEP4602925A1mixture

Publication Date: 2025.08.20 A W P SPA

AI summary

A mixture is described comprising: at least one organic or inorganic acid with bactericidal and/or bacteriostatic properties; at least one essential oil with anti-inflammatory and antioxidant properties; at least one fatty acid; at least one plant extract; at least one carrier substance.