Acidic Citrate Dialysis Package with Oxygen Permeation
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Solution Overview
Problem
Existing dialysis fluids with citric acid have pH levels below 2, which are corrosive and pose handling risks, and also lead to glucose degradation products, causing discoloration and stability issues, necessitating a package that maintains pH above 2 and allows oxygen permeation to minimize these issues.
Innovation Solution
A package containing an acidic citrate concentrate with a citric acid to citrate ratio of 75:25 to 85:15, and a pH of 2 to 3, made of polyolefin materials with an oxygen permeation rate of more than 2 g/m2/24 h at 25° C./90% RH, allowing for the creation of a ready-to-use dialysis fluid with a pH close to physiological levels and reducing glucose degradation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the pH of the dialysis fluid is lowered below 2 to increase citrate solubility and buffering capacity, then the buffering performance is improved, but the fluid becomes corrosive and causes handling risks
Solution Approach 1:
The patent changes the pH parameter from below 2 to above 2, and adjusts the citrate concentration to 28-45 mM to achieve the desired buffering capacity without corrosiveness. This parameter optimization resolves the contradiction between buffering performance and safety.
2Reliability
If the pH of the dialysis fluid is lowered below 2 to enhance acid-base balance control, then the acid-base buffering is improved, but glucose degradation products increase causing discoloration and stability issues
Solution Approach 1:
The patent optimizes the pH to be above 2 and adjusts the citrate concentration to 28-45 mM, which provides sufficient acid-base buffering while minimizing glucose degradation. This parameter optimization resolves the contradiction between buffering control and glucose stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a non-corrosive, stable dialysis fluid with reduced glucose degradation and discoloration, maintaining a pH close to physiological levels, thus improving patient safety and treatment efficacy.
Implementation Method 1
The package is made of polyolefin materials with an oxygen permeation rate of more than 2 g/m2/24 h at 25° C./90% RH, allowing for the creation of a ready-to-use dialysis fluid with a pH close to physiological levels and reducing glucose degradation
Data Source
AI summary
The present invention concerns a package comprising an acidic citrate containing concentrate, an acidic citrate containing concentrate (or acidic citrate containing solution), and a system wherein the acidic citrate containing concentrate is included for providing a dialysis treatment. The acidic citrate containing concentrate contains citric acid and citrate in a molar ratio of 75:25 to 85:15, and has a pH of between 2 and 3.