Acidic Genital Microbiome Composition for Acinetobacter Reduction
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Solution Overview
Problem
There is a need for compositions that can modulate the genital microbiome to decrease Acinetobacter populations without harming genital tissues and preserve beneficial microbiota, addressing issues such as infections, inflammation, and cancer risks.
Innovation Solution
Topical compositions comprising prebiotic oligosaccharides, metal cofactors, and borneol or its prodrugs, with an acidic pH, are applied to the urogenital and anogenital regions to reduce Acinetobacter species while supporting beneficial microbiota.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antimicrobials and biocides are used to decrease Acinetobacter populations, then Acinetobacter infection risk is reduced, but genital tissues are harmed and beneficial microbiota are destroyed
Solution Approach 1:
The patent converts the harmful effect of acidic environments (which naturally inhibit Acinetobacter) into a beneficial therapeutic mechanism. By formulating compositions with acidic pH (4.0-6.0), the invention harnesses acid-mediated selective pressure to suppress Acinetobacter while preserving beneficial microbiota, thereby converting a potentially harmful acidic environment into a protective therapeutic effect that eliminates the need for harsh antimicrobials
Solution Approach 2:
The invention changes the pH parameter of the genital environment through topical composition application. By maintaining an acidic pH range (4.0-6.0), the composition creates unfavorable conditions for Acinetobacter growth while being compatible with healthy genital tissues. This parameter modification allows selective suppression of pathogenic bacteria without the need for destructive antimicrobial agents
2Reliability
If harsh antimicrobials are applied to decrease Acinetobacter, then pathogen population is reduced, but beneficial microbiota are destroyed
Solution Approach 1:
The patent applies local quality by creating a localized acidic environment (pH 4.0-6.0) specifically at the site of Acinetobacter infection through topical composition application. This localized acidic zone selectively suppresses Acinetobacter while leaving the rest of the genital microbiome intact and beneficial species unaffected, thereby achieving pathogen control without global microbiota destruction
Solution Approach 2:
The invention converts the potentially harmful effect of acid on bacteria into a beneficial selective pressure mechanism. The acidic pH (4.0-6.0) creates an environment that naturally inhibits Acinetobacter growth while being compatible with beneficial microbiota, thereby eliminating the need for destructive antimicrobials that would harm beneficial species
3Reliability
If products are used to modulate genital microbiome, then Acinetobacter populations decrease, but irritation and inflammation increase
Solution Approach 1:
The invention modifies the pH parameter to an acidic range (4.0-6.0) that is naturally compatible with healthy genital tissues. This parameter change allows Acinetobacter suppression through selective pressure rather than through irritating or inflaming agents, thereby achieving pathogen reduction without compromising tissue health
Solution Approach 2:
The patent employs the body's own acidic environment as a therapeutic tool. By maintaining pH in the natural acidic range (4.0-6.0), the composition allows the genital microbiome's inherent acid-mediated protection to function as a self-service mechanism for Acinetobacter suppression, eliminating the need for external irritating or inflaming agents
Data Source
AI summary
The present disclosure provides compositions and methods for compositions for use in optimizing the genital microbiome of a user or sexual partners of that user. The compositions may comprise a prebiotic oligosaccharide, a metal co-factor, and an essential oil comprising bornyl acetate. The compositions support the genital microbiota and are useful for, for example, decreasing the growth of pathogenic bacteria such as bacteria from the species Acinetobacter. Furthermore, the compositions may have minimal or beneficial effect on gametes.