Acidic pH Anticoagulant for Blood Component Separation
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Solution Overview
Problem
Current methods for separating whole blood into components, such as plasma, platelets, and red blood cells, face inefficiencies in platelet collection and leukoreduction, with platelets clumping when processed on the same day and leukoreduction being less effective in stored blood, due to differences in pH and anticoagulant usage.
Innovation Solution
The method involves adding an anticoagulant with an acidic pH to whole blood, allowing for immediate separation and leukoreduction by adjusting the pH of the anticoagulant to around 6.8, either through adding citric acid or using ACDA, to prevent platelet clumping and enhance leukoreduction efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If whole blood is processed on the same day with traditional anticoagulants, then platelet collection is attempted, but platelets clump and collection efficiency decreases
Solution Approach 1:
The patent changes the pH parameter of the anticoagulant from neutral (CPD) to acidic (pH 6.8-7.0) to prevent platelet clumping and improve both platelet collection efficiency and quality when processing blood on the same day
2Reliability
If whole blood is stored overnight before processing, then leukoreduction is improved, but platelet clumping occurs and platelet yield decreases
Solution Approach 1:
The patent changes the pH parameter of the anticoagulant to acidic (pH 6.8-7.0) which maintains leukoreduction effectiveness while preventing platelet clumping during storage, thereby improving platelet yield
3Duration of action of stationary object
If neutral pH anticoagulant (CPD) is used, then blood storage is maintained, but platelet clumping occurs and leukoreduction is less effective
Solution Approach 1:
The patent changes the pH parameter of the anticoagulant from neutral to acidic (pH 6.8-7.0), which maintains blood storage stability while significantly improving separation effectiveness and reducing platelet clumping
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables efficient platelet collection and leukoreduction, improving platelet yield and reducing clumping, while maintaining effective leukoreduction, even when processing blood on the same day or after storage.
Implementation Method 1
adjusting the pH of the anticoagulant to around 6.8, either through adding citric acid or using ACDA, to prevent platelet clumping
Implementation Method 2
spinning the bag on the rotor to separate the whole blood into desired components
Implementation Method 3
squeezing the bag on the rotor to push the desired components from the separation bag into satellite bags
Data Source
AI summary
This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.