Myrtle and Tripterygium Extract Composition for Acne Phylotype Rebalancing
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Solution Overview
Problem
Current acne treatments often fail to address the imbalance in Cutibacterium acnes phylotypes, leading to ineffective treatment of non-lesional areas and the development of resistant bacterial strains, particularly due to biofilm formation, without adequately balancing the skin microbiota.
Innovation Solution
Cosmetic or dermatological compositions containing myrtle extract and Tripterygium wilfordii extracts are used to rebalance the phylotypes of Cutibacterium acnes in non-lesional areas by decreasing the pro-pathogenic IC phylotype and increasing the IB phylotype, thereby treating and preventing acne.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional acne treatments are used, then acne lesions are targeted, but the imbalance in C. acnes phylotypes persists and resistant strains develop
Solution Approach 1:
The invention changes the approach from targeting acne lesions to targeting the phylotype composition parameter itself. The composition specifically modifies the ratio of C. acnes phylotypes (increasing IB, decreasing IC) rather than simply reducing bacterial load, thereby addressing the root cause of treatment failure and resistance development.
Solution Approach 2:
The plant extracts (myrtle and Tripterygium wilfordii) act as intermediaries that selectively influence C. acnes phylotypes without completely eradicating the bacteria. This intermediary approach allows modulation of the bacterial community structure while maintaining skin homeostasis, avoiding the harsh effects of conventional antimicrobials that drive resistance.
2Quantity of substance
If antimicrobial treatments are applied, then bacterial load is reduced, but skin microbiota balance is disrupted and biofilm formation increases
Solution Approach 1:
The invention applies local quality by targeting specific phylotypes (IC reduction) while preserving others (IB increase). Rather than uniform antimicrobial action that disrupts the entire microbiota, the composition selectively modulates the phylotype distribution, maintaining overall microbiota stability while addressing the pathogenic component.
Solution Approach 2:
The invention converts the presence of C. acnes from a harmful factor to a beneficial one by selectively increasing the IB phylotype, which is associated with healthy skin. Instead of eliminating all C. acnes (which are commensal bacteria), the treatment harnesses the beneficial phylotype to restore microbiota balance and reduce inflammation.
3Reliability
If aggressive acne treatments are used, then visible lesions improve, but subclinical areas remain untreated and scarring occurs
Solution Approach 1:
The composition has universal applicability by simultaneously addressing both lesional and non-lesional areas through a single mechanism: phylotype rebalancing. The same composition that reduces inflammatory lesions also prevents new lesion formation in subclinical areas by correcting the underlying phylotype imbalance, providing multi-functional benefit.
Solution Approach 2:
The invention performs preliminary action by addressing the phylotype imbalance in non-lesional areas before lesions develop. By correcting the microbial environment in subclinical areas, the treatment prevents the formation of new lesions and reduces the risk of scarring, acting preventively rather than reactively.
Data Source
Figure 1
AI summary
The present invention relates to a cosmetic or dermatological composition comprising a myrtle extract and a Tripterygium wilfordii extract, in particular with at least one cosmetically acceptable or dermatologically acceptable excipient, for use in the treatment and/or prevention of acne of non-lesional areas of an acneic skin.