Acoustic Trauma Deafness Model Animal Production
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Solution Overview
Problem
Conventional deafness model animals, particularly acoustic trauma models, exhibit inconsistent sound pressure loads and varying hearing levels, hindering research and clinical applications due to differences between animal models and humans.
Innovation Solution
A method involving exposure of non-human primate animals, such as common marmosets, to specific sound frequencies (1 kHz to 32 kHz) and sound pressure levels (100 dB to 150 dB) for controlled durations (10 minutes to 360 minutes) under anesthesia, to reproducibly produce an acoustic trauma deafness model with consistent hearing impairment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods are used to produce acoustic trauma deafness model animals, then the production process is simple, but the hearing levels of the animals vary and the sound pressure loads are insufficient
Solution Approach 1:
The patent applies parameter changes by precisely controlling sound exposure parameters including frequency (1-32 kHz), sound pressure level (100-150 dB), and duration (10-360 minutes). This systematic parameter optimization ensures consistent acoustic trauma deafness model production while maintaining operational simplicity through standardized protocols.
2Adaptability or versatility
If conventional deafness model animals are used, then the research can be conducted with existing models, but the clinical application to humans is problematic due to differences in inner ear structure and communication systems
Solution Approach 1:
The patent selects non-human primate animals and applies specific sound exposure parameters (1-32 kHz frequency range, 100-150 dB sound pressure level, 10-360 minutes duration) to produce acoustic trauma deafness models that closely resemble human hearing loss conditions, thereby improving clinical applicability while maintaining standardized production protocols.
3Manufacturing precision
If the sound pressure level is increased to produce acoustic trauma, then the hearing loss is more pronounced, but the variability in hearing levels increases
Solution Approach 1:
The patent employs precise parameter control including sound pressure level (100-150 dB), frequency (1-32 kHz), and exposure duration (10-360 minutes) to achieve consistent acoustic trauma deafness induction. This systematic parameter optimization ensures both pronounced hearing loss and high reproducibility across different animal subjects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method enables the creation of a reliable acoustic trauma deafness model with consistent hearing loss, applicable to human clinical research, reducing measurement errors and facilitating precise audiometry and treatment development.
Implementation Method 1
exposing a non-human primate animal to a sound having a frequency of 1 kHz to 32 kHz and a sound pressure level of 100 dB to 150 dB for 10 minutes to 360 minutes
Data Source
AI summary
A method for producing a new deafness model animal and a new deafness model animal produced by the method, enabling research that can also be applied to clinical application to a human. The present invention provides a method for producing an acoustic trauma deafness model animal, the method including exposing a non-human primate animal to a sound having a frequency of 1 kHz to 32 kHz and a sound pressure level of 100 dB to 150 dB for 10 minutes to 360 minutes. In addition, the present invention provides an acoustic trauma deafness model animal provided by the method for producing an acoustic trauma deafness model animal.