AcSDKP Tetrapeptide Skin Restructuring via Fibroblast Stimulation

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Solution Overview

Problem

Current cosmetic products for anti-aging and skin restructuring often have temporary effects, are toxic, and involve costly chemical synthesis or extraction processes, failing to simultaneously target multiple protein components in the skin effectively.

Innovation Solution

The use of natural tetrapeptides or their analogues, such as derivatives of Acetyl-Ser-Asp-Lys-Pro (AcSDKP), which act on both the dermis and epidermis to stimulate the production of collagen III and IV, fibronectin, glycosaminoglycans, and keratin, improving skin elasticity and reducing wrinkles, and can be easily isolated or synthesized with minimal toxicity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If current cosmetic products are used for anti-aging and skin restructuring, then skin appearance is temporarily improved, but the effects are temporary and require repeated application

Engineering Contradiction:

Improveduration of anti-aging effectVSAvoidfrequency of reapplication

Core Design Contradiction:

Duration of action of moving objectVSLoss of time

Solution Approach 1:

The patent applies preliminary action by stimulating fibroblasts to pre-produce collagen and other structural proteins before aging signs become severe. The tetrapeptide AcSDKP activates fibroblasts in advance to synthesize collagen type I, III, and IV, elastin, and proteoglycans, creating a reservoir of structural proteins that provide prolonged anti-aging effects and reduce the need for frequent reapplication.

Inventive Principle:

Principle #10Preliminary action

2Ease of manufacture

If chemical synthesis or extraction processes are used to produce cosmetic ingredients, then active ingredients are obtained, but the processes are costly and may be toxic

Engineering Contradiction:

Improvemanufacturing cost and complexityVSAvoidtoxicity of cosmetic ingredients

Core Design Contradiction:

Ease of manufactureVSObject-affected harmful factors

Solution Approach 1:

The patent applies self-service by enabling the skin's own fibroblasts to produce the required collagen and structural proteins endogenously. Instead of externally applying synthetic ingredients, the tetrapeptide AcSDKP triggers the skin's intrinsic cellular machinery to synthesize collagen type I, III, and IV, elastin, and proteoglycans, eliminating the need for costly extraction or synthesis processes and avoiding associated toxicities.

Inventive Principle:

Principle #25Self-service

3Adaptability or versatility

If current cosmetic products target single protein components, then specific skin issues are addressed, but multiple protein components are not targeted simultaneously

Engineering Contradiction:

Improvenumber of protein targetsVSAvoidnumber of active ingredients

Core Design Contradiction:

Adaptability or versatilityVSQuantity of substance

Solution Approach 1:

The patent applies universality by using a single tetrapeptide ingredient (AcSDKP) that performs multiple functions simultaneously. This one compound targets multiple protein components including collagen type I, III, and IV, elastin, fibronectin, and proteoglycans, activating fibroblasts to produce all these structural proteins together, thereby addressing multiple aging signs with a single active ingredient rather than requiring combinations of multiple substances.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS8697652B2Cosmetic use of at least the natural tetrapeptide Ac-Ser-Asp-Lys-Pro or one of its analogs as a skin restructuring agent

Publication Date: 2014.04.15 CENT NAT DE LA RECH SCI (C N R S)

AI summary

This invention relates to the cosmetic use of at least one compound of formula (I)whereinA1 is the radical corresponding to D- or L-SerA2 is the radical corresponding to D- or L-Asp or Glu,A3 is the radical corresponding to D- or L-Lys, Arg or Orn,A4 is the radical corresponding to D- or L-pro,R1, R2 and R3 are as defined in the claims as anti-aging and restructuring agents.