Active Charge-Balancing Circuit for High-Frequency Neural Stimulation

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

High-frequency neural stimulation devices face challenges in active charge-balancing, leading to potential nerve and electrode damage due to residual charge buildup, which is not adequately addressed by existing technologies.

Innovation Solution

A neural stimulation apparatus with a system that applies currents of opposite polarities during stimulation and recovery phases, using a sensing circuit to determine charge buildup and a compensation circuit to apply a delta current, minimizing residual charge through a balancing circuitry that includes an H-bridge circuit and current sources, effectively managing charge across electrodes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If high-frequency neural stimulation is applied, then therapeutic benefit is improved, but residual charge buildup increases causing nerve and electrode damage

Engineering Contradiction:
Improvestimulation frequencyVSAvoidresidual charge buildup
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent implements a feedback mechanism where the circuit monitors the charge state of the capacitor and dynamically adjusts the charge-balancing operation. The control circuit detects residual charge conditions and triggers compensatory charge-balancing pulses only when needed, rather than continuously balancing. This feedback-based approach enables high-frequency stimulation while preventing harmful charge accumulation through intelligent, condition-based intervention.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent changes the operational parameters of the charge-balancing circuit by switching between different charge-balancing modes (e.g., different pulse widths, amplitudes, or timing) based on the stimulation phase and detected charge conditions. The circuit adjusts charge-balancing parameters dynamically during high-frequency operation to maintain safety while preserving therapeutic efficacy, rather than using fixed charge-balancing parameters.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If charge-balancing operation is performed continuously, then residual charge is minimized, but power consumption and device complexity increase

Engineering Contradiction:
Improvecharge balancing effectivenessVSAvoidpower consumption
Core Design Contradiction:
ReliabilityVSUse of energy by moving object

Solution Approach 1:

The control circuit continuously monitors capacitor charge state through voltage sensing and only activates charge-balancing operations when residual charge exceeds safe thresholds. This feedback-driven selective operation maintains reliable charge management while dramatically reducing power consumption compared to continuous charge-balancing, as the balancing circuit remains inactive during most high-frequency stimulation cycles when charge accumulation is not problematic.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

Instead of continuous charge-balancing, the patent implements periodic charge-balancing operations synchronized with the stimulation protocol. Charge-balancing pulses are applied at specific intervals or phases (e.g., after a predetermined number of stimulation pulses or when voltage thresholds are reached), creating a periodic rather than continuous operation mode that reduces overall power consumption while maintaining safety.

Inventive Principle:
Principle #19Periodic action

3Reliability

If charge-balancing operation is performed continuously, then residual charge is minimized, but device complexity increases

Engineering Contradiction:
Improvecharge balancing effectivenessVSAvoidcircuit complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The control circuit uses simple voltage threshold detection and conditional logic to determine when charge-balancing is needed, avoiding complex continuous control algorithms. The feedback mechanism relies on straightforward comparisons of capacitor voltage against predefined thresholds, triggering charge-balancing only when necessary. This simplified feedback approach maintains effective charge management while minimizing circuit complexity compared to continuous active control systems.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent extracts the charge-balancing function as a separate, independently controlled subsystem rather than integrating it continuously into the main stimulation circuit. The charge-balancing circuit is activated only when specific conditions are met, allowing it to be designed as a modular add-on component rather than a fully integrated continuous system, thereby reducing overall device complexity.

Inventive Principle:
Principle #2Taking out (Extraction)

Data Source

PatentEP3538203B1Systems and methods for active charge-balancing for high-frequency neural stimulation
Publication Date: 2024.02.28 VERILY LIFE SCIENCES LLC
  • EP3538203B1 patent drawingFigure 1
  • EP3538203B1 patent drawingFigure 2
  • EP3538203B1 patent drawingFigure 3

AI summary

Systems and methods for active charge-balancing for high frequency neural stimulation are disclosed. One illustrative method described herein includes: applying, through a pair of electrodes electrically coupled to a bundle of nerve fibers during a stimulation phase of a neural stimulation procedure, a first current to the bundle of nerve fibers; applying, through the pair of electrodes during a recovery phase of the neural stimulation procedure, a second current to the bundle of nerve fibers, the first current and the second current having opposite polarities; determining sampled voltages between the pair of electrodes during the stimulation phase, during the recovery phase, or between the stimulation phase and the recovery phase; determining a charge buildup in the bundle of nerve fibers based on the sampled voltages; applying, through the pair of electrodes during the stimulation phase or during the recovery phase, a delta current to the bundle of nerves based on the sampled voltages to minimize the charge build up.