Active Micro-Shunt for Dynamic IOP Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current minimally invasive glaucoma surgery (MIGS) devices lack dynamic solutions for controlled intraocular pressure (IOP) management, relying on static drainage with limited flexibility and no continuous data monitoring, which hampers effective IOP regulation and drug delivery.
Innovation Solution
An implantable active micro-shunt device with a 3D integrated layer stack and MEMS technology for real-time IOP sensing and electrohydrodynamic actuation, enabling active and passive drainage, and on-demand drug delivery to dynamically regulate IOP and fluid flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If passive mechanical drainage devices are used, then device complexity is reduced, but IOP control flexibility and adaptability deteriorate
Solution Approach 1:
The patent implements dynamic IOP control by transitioning from static passive drainage to an active pump system that can adjust flow rates in real-time. The pump mechanism allows the device to adapt to varying IOP levels and circadian patterns, providing dynamic rather than fixed drainage characteristics.
Solution Approach 2:
The patent incorporates continuous IOP monitoring with feedback control mechanisms. The system measures actual IOP levels and adjusts pump operation accordingly, creating a closed-loop control system that adapts to patient-specific IOP patterns and circadian variations, thereby improving flexibility without proportionally increasing complexity.
2Device complexity
If fixed hydraulic resistance is provided, then device complexity is reduced, but IOP regulation precision deteriorates
Solution Approach 1:
The patent replaces fixed hydraulic resistance with a dynamically adjustable pump system that can modulate flow rates based on real-time IOP measurements. This dynamic adjustment capability enables precise IOP regulation that adapts to circadian patterns and individual patient needs, achieving higher precision without manufacturing complexity.
Solution Approach 2:
The patent implements variable hydraulic resistance through controlled pump operation rather than fixed physical resistance. By changing the operational parameters of the pump (flow rate, activation timing), the system achieves precise IOP control that can be adjusted according to circadian rhythms and patient-specific requirements.
3Measurement precision
If continuous IOP monitoring is implemented, then IOP control precision is improved, but device complexity and energy consumption increase
Solution Approach 1:
The patent integrates continuous IOP sensing with feedback control, where the measured IOP data directly drives pump operation. This closed-loop system uses the precision measurements to regulate drainage in real-time, creating a self-adjusting mechanism that improves control precision while managing complexity through integrated design.
Solution Approach 2:
The patent implements a self-regulating system where the pump automatically adjusts its operation based on real-time IOP feedback without requiring external intervention. The continuous monitoring and automatic response create a self-service mechanism that improves precision while minimizing the need for additional complex external control systems.
4Measurement precision
If active pump function is added, then IOP control precision is improved, but device complexity and manufacturing difficulty increase
Solution Approach 1:
The patent combines the pump function with IOP monitoring and control electronics into an integrated device. By merging these functions into a single unit with shared components, the patent reduces overall manufacturing complexity compared to having separate systems, while still achieving precise IOP control through the active pump mechanism.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides enhanced IOP control and consistency by actively managing fluid drainage and drug delivery, improving treatment efficacy for glaucoma and other conditions by adapting to dynamic IOP fluctuations and body position changes.
Implementation Method 1
a pressure sensor configured for measurement of intraocular pressure (IOP)
Implementation Method 2
an electrohydrodynamic actuator configured for generation of fluid flow forces
Data Source
AI summary
The disclosed apparatus, systems and methods relate to a smart minimally invasive glaucoma surgery (Smart-MIGS) device configured for passive and active flow. Various implementations are defined by a combination device that integrates intraocular pressure (IOP) monitoring, drug delivery and a drainage function for pressure control in the body or bodily region of a subject.