Active Oxygen Antiseptic Composition for Biofilm-Safe Wound Irrigation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current wound lavage solutions, such as povidone-iodine and triple salts, are ineffective against surgical site infections, potentially toxic, and can lead to antibiotic resistance, with limited antimicrobial activity and detrimental effects on tissue, and have slow reaction times and limited shelf life.
Innovation Solution
A stabilized active oxygen-generating antiseptic composition comprising a matrix of sulfate and persulfate with a ratio of at least 8:2, which produces active oxygen species like singlet O2, ozone, and peroxide to eradicate bacteria, fungi, and viruses, including biofilms, without causing tissue damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If povidone-iodine is used for wound lavage, then antimicrobial activity is provided, but tissue damage and metabolic toxicity occur
Solution Approach 1:
The patent changes the chemical composition parameters by using a sulfate/persulfate system instead of povidone-iodine, maintaining antimicrobial efficacy while eliminating iodine-related tissue toxicity and metabolic side effects
Solution Approach 2:
The invention extracts and eliminates the harmful iodine component from the antiseptic system while retaining the desired antimicrobial function through an oxygen-based mechanism that does not damage tissue
2Use of energy by moving object
If triple salts are used for wound lavage, then oxidative effects are provided, but antimicrobial activity is limited due to slow transformation rate
Solution Approach 1:
The patent optimizes the sulfate to persulfate ratio (at least 8:2) to accelerate the solid-to-liquid transformation rate and control the release kinetics of active oxygen, thereby enhancing antimicrobial productivity while maintaining oxidative effects
Solution Approach 2:
The composition is prepared in advance with optimized ratios of sulfate and persulfate to ensure rapid and effective antimicrobial action when applied, eliminating the slow transformation delay
3Reliability
If antibiotics are used for wound lavage, then antimicrobial effectiveness is improved, but antibiotic resistance develops and cost increases
Solution Approach 1:
The patent converts the harmful mechanism of antibiotic resistance into a beneficial oxygen-based antimicrobial mechanism that kills bacteria through oxidative stress rather than targeted inhibition, preventing resistance development while maintaining effectiveness
Solution Approach 2:
The invention changes the fundamental mechanism of action from chemical inhibition (antibiotics) to oxidative destruction (active oxygen species), providing broad-spectrum antimicrobial effectiveness without selecting for resistant strains
4Reliability
If surfactants are used for wound lavage, then bacterial load is reduced, but osteoblast/osteoclast cell lines are damaged
Solution Approach 1:
The patent changes the chemical nature of the antiseptic from surfactant-based to oxygen-based, achieving bacterial load reduction through oxidative mechanisms that do not interfere with bone cell function and may actually promote tissue regeneration
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides broad-spectrum antimicrobial activity, eradicates biofilms, reduces post-operative infections, and promotes tissue regeneration with controlled active oxygen release, avoiding resistance and toxicity issues.
Implementation Method 1
stabilized active oxygen-generating antiseptic composition comprising a matrix of sulfate and persulfate with a ratio of at least 8:2, which produces active oxygen species like singlet O2, ozone, and peroxide
Implementation Method 2
stabilized active oxygen-generating antiseptic composition comprising a matrix of sulfate and persulfate with a ratio of at least 8:2, which produces active oxygen species
Data Source
Figure 1
Figure 2
Figure 3
AI summary
A stabilized active oxygen-generating antiseptic composition is disclosed including at least one of an antiseptic mixture or an antiseptic polymer. The antiseptic mixture includes a persulfate distributed in a matrix of a sulfate wherein the antiseptic composition is characterized by a ratio of the sulfate to the persulfate of at least 8:2. The antiseptic polymer is formed by the reaction of a sulfate, a persulfate, and amino acid in a reaction solution having a ratio of the sulfate to the persulfate of at least 6:4 and a ratio of the amino acid to the sulfate and the persulfate combined of 1:2 to 2:1. An antiseptic irrigation solution is disclosed including the antiseptic composition dispersed in a solvent. An antiseptic article is disclosed including an article and at least one of the antiseptic composition or an antiseptic coating formed from the antiseptic composition disposed on a surface of the article.