Active Peptide Composition for ROCK-Targeted Skin Anti-Aging

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Solution Overview

Problem

Existing technologies lack effective skin anti-aging and repair solutions targeting Rho-associated protein kinase (ROCK), which contributes to cellular senescence and apoptosis, leading to skin aging and impaired barrier function.

Innovation Solution

Development of peptides that inhibit ROCK activity, formulated into compositions for anti-aging and repair, enhancing fibroblast activity, promoting collagen synthesis, and improving skin elasticity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If ROCK activity is inhibited, then cellular senescence and apoptosis are delayed, but existing ROCK inhibitors have not been effectively applied to skin anti-aging and repair

Engineering Contradiction:

Improveskin anti-aging effectVSAvoidapplication to skin repair

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent modifies the molecular structure of ROCK inhibitors by changing chemical parameters (introducing specific amino acid sequences like Lys-Arg-Tyr-Gly-Trp-Lys) to create peptides optimized for skin anti-aging and repair applications, transforming general ROCK inhibition into skin-specific efficacy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses peptide compounds as intermediary substances that bridge the gap between ROCK inhibition mechanism and skin repair outcome, with the peptides serving as deliverable agents that can be applied topically to achieve both anti-aging and repair effects

Inventive Principle:

Principle #24Intermediary (Mediator)

2Duration of action of stationary object

If cellular senescence is delayed, then skin aging is reduced, but skin barrier function and metabolism remain impaired

Engineering Contradiction:

Improvecell lifespanVSAvoidskin barrier function

Core Design Contradiction:

Duration of action of stationary objectVSReliability

Solution Approach 1:

The patent designs peptides that perform multiple functions simultaneously: inhibiting ROCK activity to delay cellular senescence while also promoting collagen synthesis and improving skin barrier function, making a single agent effective across multiple skin health parameters

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent creates composite peptide structures combining multiple amino acid residues (Lys, Arg, Tyr, Gly, Trp) that work synergistically to achieve both anti-aging through ROCK inhibition and barrier repair through collagen promotion

Inventive Principle:

Principle #40Composite materials

3Reliability

If ROCK inhibitors are developed, then anti-aging effect is improved, but manufacturing and formulation complexity increases

Engineering Contradiction:

Improveanti-aging efficacyVSAvoidpeptide formulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent segments the complex ROCK inhibition function into specific peptide sequences (Formula I structure) that can be synthesized independently and formulated separately, allowing for simplified production and combination with other skin care ingredients

Inventive Principle:

Principle #1Segmentation

Data Source

PatentEP4700038A1Active peptide, and composition and use thereof

Publication Date: 2026.02.25 WINKEY TECHNOLOGY USA INC

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AI summary

A peptide of formula (I), i.e., R1-Wm-AA1-AA2-AA3-AA4-Trp-AA5-Xn-Yp-Zq-R2, a stereoisomer thereof, a mixture of stereoisomers thereof, a salt thereof, or a composition thereof, and a use thereof in the preparation of a composition for inhibiting ROCK activity, preventing aging or photoaging, and implementing anti-aging repair and moisturization.