Acute Decompensated Heart Failure Fluid Control By Urine Feedback

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Solution Overview

Problem

Existing treatments for acute decompensated heart failure (ADHF) using diuretics are unpredictable in their short-term effects, leading to uncertainties in dosing and potential complications such as hypotension and prolonged hospital stays due to variable urine output responses.

Innovation Solution

Combining diuretics with a fluid management device like the RenalGuard system to control fluid infusion based on urine output feedback, allowing higher diuretic doses and automatic adjustments to prevent hypotension, promoting rapid fluid reduction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If diuretics are administered to reduce fluid levels in ADHF patients, then fluid removal effectiveness is improved, but urine output becomes unpredictable leading to dosing uncertainties and potential complications

Engineering Contradiction:

Improvefluid removal effectivenessVSAvoidurine output predictability

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent implements a feedback control system where urine output is continuously monitored and used to adjust the fluid infusion rate. The controller receives urine output signals and automatically modifies the infusion rate to maintain target urine production, transforming the unpredictable diuretic response into a controlled process with reliable outcomes

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The system enables self-regulation of fluid management by using the patient's own urine output as the control signal. The automated system adjusts infusion based on real-time physiological response without requiring continuous manual intervention, allowing the treatment to self-optimize based on individual patient response

Inventive Principle:

Principle #25Self-service

2Object-affected harmful factors

If conservative (low) diuretic dosage is prescribed to avoid complications, then patient safety is improved, but treatment duration is prolonged and symptoms may worsen

Engineering Contradiction:

Improvepatient safetyVSAvoidtreatment duration

Core Design Contradiction:

Object-affected harmful factorsVSLoss of time

Solution Approach 1:

The system dynamically adjusts the fluid infusion rate based on real-time urine output monitoring. Rather than using fixed conservative dosing, the automated feedback control allows the infusion rate to adapt continuously to patient response, enabling safe yet aggressive fluid removal when appropriate while preventing complications through real-time monitoring and adjustment

Inventive Principle:

Principle #15Dynamics

3Productivity

If high diuretic doses are used to achieve rapid fluid reduction, then treatment effectiveness is improved, but risk of hypotension and vital organ damage increases

Engineering Contradiction:

Improvefluid reduction rateVSAvoidhypotension risk

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The feedback control system continuously monitors urine output and automatically adjusts fluid infusion to prevent excessive fluid removal. By using urine production rate as the control signal, the system ensures that high diuretic doses are matched by adequate fluid replacement only when needed to maintain urine output, preventing hypotension and organ damage while achieving rapid decongestion

Inventive Principle:

Principle #23Feedback

4Productivity

If fluid infusion is used to promote urine output, then urine production is improved, but intravascular fluid levels may increase causing concern about worsening overload

Engineering Contradiction:

Improveurine output rateVSAvoidintravascular fluid volume

Core Design Contradiction:

ProductivityVSQuantity of substance

Solution Approach 1:

The system uses urine output as the primary feedback signal to control fluid infusion rates. By tying infusion directly to actual urine production rather than estimated needs, the system ensures that fluid is replaced only at the rate it is being excreted, maintaining a balanced approach that promotes urine output without causing fluid accumulation. The net effect is fluid removal while sustaining kidney function

Inventive Principle:

Principle #23Feedback

Data Source

PatentUS20250319252A1Method and system to treat acute decompensated heart failure

Publication Date: 2025.10.16 REPRIEVE CARDIOVASCULAR INC

AI summary

A apparatus and method to treat patients with acute decompensated heart failure (ADHF), heart failure or another fluid overload condition, that includes: administrating a diuretic to the patient to increase urine output of the patient; monitoring a rate or amount of urine output by the patient after administration of the diuretic; infusing a hydration liquid into the patient to induce an increase in the urine output; and adjusting the rate or amount of the hydration liquid infused into the patient to achieve a target fluid loss in the patient.