Acyl Lactylate Purification via pH-Controlled Extraction

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Solution Overview

Problem

Existing processes for synthesizing acyl lactylates result in mixtures containing lactic acid and fatty acid, making it difficult to achieve high-purity separation due to the strong hydrophobic nature of the components, which hinders effective liquid-liquid extraction.

Innovation Solution

A method involving dispersion in a polar carrier, adjusting the pH to 5-9, and extracting fatty acid into an immiscible solvent, followed by multi-stage counter-current extraction, allows for the separation of fatty acid and acyl lactylate from the mixture, enabling the recovery of high-purity products.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If liquid-liquid extraction is used to separate fatty acid and acyl lactylate, then separation is attempted, but the strong hydrophobic nature of both components causes them to remain in the same phase, making separation ineffective

Engineering Contradiction:
Improvepurity of separated componentsVSAvoidhydrophobicity preventing phase separation
Core Design Contradiction:
Manufacturing precisionVSObject-generated harmful factors

Solution Approach 1:

The invention changes the pH parameter of the aqueous phase to separate components based on their acid-base properties. Fatty acids are extracted at pH 2-4 where they remain protonated and hydrophobic, while acyl lactylates are extracted at pH 8-10 where they are deprotonated and hydrophilic, enabling effective liquid-liquid extraction despite both components' hydrophobic character

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention uses pH adjustment as an intermediary mechanism to modify the extraction behavior of components. By controlling the protonation state through pH, the process creates differential solubility in the aqueous-organic system, allowing selective extraction of fatty acids and acyl lactylates into different phases

Inventive Principle:
Principle #24Intermediary (Mediator)

2Ease of manufacture

If conventional extraction methods are used, then the process is simple, but the product purity remains low due to co-extraction of fatty acid and acyl lactylate

Engineering Contradiction:
Improvesimplicity of extraction processVSAvoidpurity of acyl lactylate product
Core Design Contradiction:
Ease of manufactureVSManufacturing precision

Solution Approach 1:

The invention performs preliminary pH adjustment before extraction to pre-condition the mixture for selective separation. The first extraction at low pH removes fatty acids before the second extraction at high pH recovers acyl lactylates, ensuring high purity products while maintaining process simplicity through sequential batch operations

Inventive Principle:
Principle #10Preliminary action

3Manufacturing precision

If multiple extraction steps are implemented to achieve high purity, then product purity increases to at least 90%, but process complexity and time increase

Engineering Contradiction:
Improvepurity of separated componentsVSAvoidtime for multi-stage extraction process
Core Design Contradiction:
Manufacturing precisionVSLoss of time

Solution Approach 1:

The invention uses periodic pH adjustment between extraction steps to achieve high purity separation. By alternating between acidic and basic conditions in sequential extractions, the process efficiently removes different components in distinct stages, achieving at least 90% purity while minimizing total processing time through optimized pH switching

Inventive Principle:
Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method effectively separates fatty acid and acyl lactylate, achieving purity levels of at least 90%, with the potential for solvent recycling, reducing costs and improving economic viability.

Implementation Method 1

providing a dispersion of said mixture in a polar carrier

Methodology Applied
Scientific EffectDispersion: Dispersion (of waves)

Implementation Method 2

extracting the fatty acid from the dispersion carrier mixture into a solvent immiscible with said polar carrier

Methodology Applied
Scientific EffectLiquid-liquid extraction: Liquid-Liquid Extraction

Implementation Method 3

allowing said acidified raffinate to separate into two layers and separating the lower, aqueous layer from the residual layer of acyl lactylate

Methodology Applied
Scientific EffectPhase separation:

Data Source

PatentEP3237368B1Lactylate purification process
Publication Date: 2020.02.12 PURAC BIOCHEM BV
  • EP3237368B1 patent drawingFigure 1
  • EP3237368B1 patent drawingFigure 2

AI summary

A method for separation of fatty acid from a mixture comprising fatty acid, the corresponding acyl lactylate and lactic acid, said method comprising the steps of: a) providing a dispersion of said mixture in a polar carrier; b) adjusting the dispersion mixture to a pH of from 5 to 9; and, c) extracting the fatty acid from the dispersion carrier mixture into a solvent immiscible with said polar carrier, thereby obtaining a fatty acid solution and an aqueous raffinate comprising lactic acid and fatty acid lactylate. The polar carrier comprises, by weight of said carrier, from 70 to 100 wt.% of water and from 0 to 30 wt.% of one or more miscible, polar co-solvents. The aqueous raffinate may be further processed by: i) acidifying said raffinate to a pH of from 0 to 3; and, either ii)a) allowing said acidified raffinate to separate into two layers and separating the lower, aqueous layer from the residual layer of acyl lactylate, or ii)b) extracting the fatty acid lactylate from the acidified raffinate into a second solvent which is immiscible with said aqueous raffinate, thereby obtaining an acyl lactylate solution.