Blood Component Separation With Adaptive Processing Volume Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing blood separation systems face inaccuracies in determining the optimal amount of blood to be processed, leading to insufficient or excessive processing time and potential depletion of the blood source, especially when collecting specific blood components like platelets.
Innovation Solution
A blood separation device with a controller that adjusts the target amount of blood to be processed based on the difference between the target and actual yields, using algorithms that incorporate machine learning techniques to refine the estimation over multiple procedures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a fixed initial target amount of blood is processed, then the separation procedure can be executed with a standardized protocol, but the accuracy of blood component collection is insufficient and may lead to depletion of the blood source
Solution Approach 1:
The system dynamically adjusts the target amount of blood to be processed based on actual yield data from previous procedures. The controller modifies the initial target amount upward or downward depending on whether the actual yield was less than or greater than the target yield, transforming a static standardized protocol into a dynamic adaptive process that optimizes collection accuracy while preventing blood source depletion
Solution Approach 2:
The system implements feedback by comparing the actual yield of blood components with the target yield after each separation procedure. This feedback loop allows the controller to learn from previous outcomes and adjust the initial target amount for subsequent procedures, improving measurement precision while maintaining reliability through data-driven decision making
2Quantity of substance
If the initial target amount of blood is increased to ensure sufficient component collection, then the target yield can be achieved, but the procedure time increases and the blood source may be depleted
Solution Approach 1:
The system performs preliminary analysis of actual yield data from previous procedures before determining the initial target amount for the current procedure. By using historical data to predict the optimal blood volume needed, the system prepares in advance with an optimized target amount that ensures sufficient component collection without requiring excessive processing time or risking blood source depletion
3Productivity
If the initial target amount of blood is decreased to reduce procedure time, then the procedure becomes faster, but the target yield of blood component may not be achieved
Solution Approach 1:
The system dynamically determines the initial target amount by analyzing actual yield data from previous procedures. This dynamic adjustment ensures that the blood volume processed is optimized for each specific case, achieving the target yield efficiently without unnecessary processing of excess blood, thereby maintaining high productivity while ensuring sufficient component collection
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Improves the accuracy of blood component collection by dynamically adjusting the processing volume, optimizing the procedure for each donor, thereby enhancing efficiency and maintaining the quality of collected components.
Implementation Method 1
The centrifuge rotates the separation chamber of the disposable flow circuit during processing, causing the heavier (greater specific gravity) components of the whole blood in the separation chamber, such as red blood cells, to move radially outwardly away from the center of rotation toward the outer or 'high-G' wall of the separation chamber. The lighter (lower specific gravity) components, such as plasma, migrate toward the inner or 'low-G' wall of the separation chamber.
Data Source
AI summary
Blood is conveyed from a source into a separator, which separates at least one target blood component from the blood. The target blood component is then conveyed out of the separator, with the procedure continuing until an initial target amount of blood to be processed has been conveyed from the source into the separator and the target blood component separated from the initial target amount of blood to be processed has been conveyed out of the separator as an actual yield of the target blood component. An adjusted target amount of blood to be processed is then determined based at least in part on the difference between a target yield of the target blood component and the actual yield. The initial target amount of blood to be processed is then replaced with the adjusted target amount of blood to be processed when next executing the procedure.