Adaptive Dose Titration for Obstructive Sleep Apnea Medication
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Solution Overview
Problem
Existing pharmacotherapy for obstructive sleep apnea (OSA) faces challenges in determining optimal medicament doses over time due to patient changes and side effects, necessitating a means to adjust doses dynamically.
Innovation Solution
A computer-implemented method and system for controlling medicament dose titration by obtaining previous dose levels and efficacy measures, considering subject response, adherence, and side effects to determine optimal future doses, using sensors and smart devices for data collection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pharmacotherapy is used to treat OSA, then treatment efficacy can be achieved, but it becomes difficult to determine optimal dose levels over time due to patient changes and side effects
Solution Approach 1:
The system dynamically adjusts medicament dose levels based on real-time patient response data and changing conditions. The dose determination is not static but adapts continuously as patients change over time in weight, sleeping body position, age, and other factors, resolving the contradiction between maintaining reliable treatment efficacy and managing dose determination complexity.
Solution Approach 2:
The system implements feedback mechanisms by monitoring patient response to medicament doses and using this information to determine subsequent dose levels. This closed-loop approach allows the system to automatically adjust doses based on observed efficacy and side effects, reducing the complexity of manual dose determination while maintaining treatment reliability.
2Manufacturing precision
If dose levels are adjusted manually based on patient response, then optimal dosing can be achieved, but this requires close monitoring and manual intervention
Solution Approach 1:
The system enables self-service by automatically determining optimal dose levels without requiring manual intervention. The system monitors patient response independently and autonomously adjusts medicament dosing, achieving precise dose optimization while eliminating the need for continuous manual monitoring and intervention.
Solution Approach 2:
The patent replaces manual mechanical dose adjustment with an automated electronic system. Sensors and processors substitute for manual monitoring and decision-making, automatically determining optimal doses based on patient response data, thereby maintaining dose precision while significantly improving ease of operation.
3Adaptability or versatility
If multiple medicament components are used, then comprehensive treatment coverage is achieved, but dose interaction and optimization become more complex
Solution Approach 1:
The system provides universal control over multiple medicament components through a single integrated platform. The same automated system manages dosing for different medicaments and delivery methods, achieving comprehensive treatment coverage while simplifying the complexity of managing multiple components through unified control.
Data Source
AI summary
The invention provides a computer-implemented method for controlling a dose titration of a medicament to be provided to a subject for treating obstructive sleep apnea. The method includes obtaining a dose level of a previous dose of the medicament, the previous dose having been provided to the subject and obtaining a medicament efficacy measure based on a response of the subject to the previous dose. A dose titration for a future dose of the medicament is determined based on the medicament efficacy measure and the dose level of the previous dose.