Adaptive Epilepsy Therapy Termination via Real-Time Signal Feedback
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current therapies for managing pharmaco-resistant seizures, such as epilepsy, lack effective optimization strategies due to inadequate measurement and control of complex brain state changes, leading to inefficient and potentially harmful treatment outcomes.
Innovation Solution
A method and system for detecting epileptic events and applying electrical therapy, with real-time monitoring and adaptation based on autonomic, neurologic, metabolic, and endocrine signals to determine efficacy, allowing for immediate termination or modification of therapy to prevent adverse effects and enhance therapeutic outcomes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If electrical therapy is applied continuously to treat epileptic seizures, then therapeutic efficacy is improved, but adverse effects and potential harm increase
Solution Approach 1:
The patent implements a feedback mechanism by monitoring body signals (autonomic, neurologic, metabolic, endocrine) in real-time during therapy delivery. The system uses this feedback to determine when the epileptic event has been controlled and automatically terminates the therapy, preventing over-treatment and adverse effects while maintaining therapeutic efficacy.
Solution Approach 2:
The therapy delivery is made dynamic and adaptive rather than static. The system continuously adjusts therapy parameters based on real-time monitoring of body signals and automatically modifies or terminates treatment when efficacy is achieved, allowing the therapy to respond to the patient's changing physiological state.
2Reliability
If therapy duration is extended to ensure complete seizure control, then therapeutic outcomes are improved, but loss of time and treatment efficiency worsen
Solution Approach 1:
The system uses real-time feedback from monitored body signals to determine when seizure control has been achieved. This allows the therapy to be terminated as soon as efficacy is demonstrated, avoiding unnecessary extension of treatment duration while ensuring complete seizure control.
Solution Approach 2:
The system establishes predetermined criteria and thresholds for seizure control before therapy begins. When these pre-defined conditions are met during treatment, the system automatically terminates therapy, eliminating the need for extended treatment duration while ensuring adequate seizure control.
3Reliability
If therapy intensity is increased to improve seizure management, then therapeutic efficacy is improved, but adverse effects and patient harm increase
Solution Approach 1:
The therapy intensity is made dynamic rather than fixed. The system continuously monitors body signals and automatically adjusts therapy parameters in real-time, delivering higher intensity only when needed for seizure control and reducing intensity or terminating when efficacy is achieved, thereby improving seizure management while minimizing patient harm.
Solution Approach 2:
The system changes therapy parameters (intensity, duration, frequency) based on real-time monitoring of physiological responses. By dynamically adjusting these parameters according to measured efficacy, the system achieves effective seizure management at the lowest necessary intensity, reducing adverse effects and patient harm.
4Measurement precision
If multiple body signals are monitored to accurately determine therapy efficacy, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The system uses a multi-functional integrated platform that can monitor multiple types of body signals (autonomic, neurologic, metabolic, endocrine) simultaneously through a single unified system. This approach improves measurement precision for efficacy determination while avoiding the complexity of multiple separate monitoring systems.
Data Source
AI summary
A method comprising detecting an epileptic event in a patient; applying an electrical therapy to a first target area in at least one of a brain region or a cranial nerve of said patient in response to said detecting; receiving a body signal responsive to the electrical therapy, wherein said body signal is selected from an autonomic signal, a neurologic signal, a metabolic signal, an endocrine signal, or a tissue stress marker signal; determining whether said body signal indicates that said electrical therapy has an efficacious effect; and terminating the application of said electrical therapy if the response indicates that the electrical therapy has an efficacious effect. An apparatus capable of performing the method. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform the method.