Adaptive Radiation Therapy Planning System Using Dose-Based Transformations
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Solution Overview
Problem
Current radiation therapy treatment plans become inaccurate due to anatomical changes between planning and delivery, leading to insufficient radiation to the target structure and excessive radiation to organs at risk, as they are adapted using rigid transformations based on anatomical comparisons rather than dose objectives.
Innovation Solution
A system and method for adapting radiation therapy treatment plans using a planning unit that determines transformations based on dose objectives, allowing for improved accuracy by rotating or translating radiation beam directions and positions, and generating adapted dose distributions to ensure treatment objectives are met, employing rigid transformations that do not require recomputation of beam parameters.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If rigid transformation based on anatomical comparison is used to adapt treatment plan, then computational complexity is reduced, but treatment objective fulfillment accuracy deteriorates
Solution Approach 1:
The invention changes the basis parameter for transformation determination from anatomical configuration comparison to dose objective fulfillment. Instead of finding transformation that aligns anatomical features, the system determines transformation parameters that optimize dose distribution according to treatment goals, directly addressing the accuracy issue while maintaining computational efficiency through parameter optimization rather than complex anatomical matching
Solution Approach 2:
The invention replaces the mechanical/anatomical-based transformation approach with a dose-objective-based optimization approach. Rather than using rigid anatomical landmarks and configurations to determine transformation, the system substitutes this with an optimization process that directly evaluates dose distribution outcomes and adjusts transformation parameters accordingly
2Ease of manufacture
If treatment plan is generated in advance based on planning image, then planning time is sufficient for complex optimization, but anatomical changes between planning and delivery cause treatment inaccuracy
Solution Approach 1:
The invention introduces dynamic adaptability to the treatment planning process by enabling transformation determination based on dose objectives that can respond to anatomical changes. The system allows the treatment plan to be dynamically adjusted through transformation optimization that considers current anatomical configuration reflected in dose distribution, rather than relying on static pre-planned transformations
Solution Approach 2:
The invention implements a feedback mechanism where dose distribution results are used to evaluate and refine transformation parameters. The system calculates dose distribution based on transformed anatomical data, compares it against treatment objectives, and uses this feedback to iteratively optimize the transformation, ensuring treatment accuracy despite anatomical changes between planning and delivery
Data Source
AI summary
In planning of radiation therapy treatment of at least one structure in a region of a patient body, a first treatment plan is generated on the basis of a planning image of the body region and on the basis of dose objectives. A further image of the body region of the patient body is received, and a transformation is determined for generating an adapted treatment plan from the first treatment plan and/or for generating an adapted dose distribution from the dose distribution corresponding to the first treatment plan on the basis of the further image and determines an adapted treatment plan on the basis of the transformation and/or the adapted dose distribution. The transformation on the basis of the dose objectives. In adapting the dose distribution, an efficient iterative dosimetric patient setup optimization may be employed to reduce the dose computations.