Additive-Free Active Pellets with Honeycomb Texture
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Solution Overview
Problem
Conventional active pellets rely on chemical additives, which can have adverse effects on human health and complicate the manufacturing process, particularly due to issues with flowability and disintegration.
Innovation Solution
Development of active pellets without chemical additives, utilizing a body composed of 50-100% active ingredient, up to 40% natural diluents, and up to 10% natural binders, with honeycomb holes or textures for improved flow and disintegration, and a covered layer for stability and controlled release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If chemical additives (polymer binder, lubricant) are used during pellet manufacturing, then workability and flowability are improved, but health safety and formulation purity deteriorate
Solution Approach 1:
The patent removes chemical additives (polymer binders, lubricants) from the pellet manufacturing process entirely. The active ingredient powder is directly compressed and spheroidized without adding any chemical substances, thereby eliminating the harmful effects of artificial additives while maintaining manufacturing workability through process optimization.
Solution Approach 2:
The patent changes the physical parameters of the active ingredient powder (particle size distribution, moisture content, compression force) to achieve adequate flowability and workability without chemical additives. By controlling particle size between 10-100 μm and optimizing compression parameters, the powder exhibits sufficient流动性 for pellet formation.
2Ease of operation
If lubricant is added to active powder, then flowability is improved, but disintegration and solubility are adversely affected
Solution Approach 1:
The patent completely eliminates lubricant from the formulation. Instead of coating the powder surface with lubricant to improve flowability, the method relies on direct compression of the active ingredient powder under controlled parameters to achieve both flowability and maintain disintegration properties.
Solution Approach 2:
The patent optimizes physical parameters (particle size distribution, compression force, moisture content) to achieve adequate flowability without lubricant. The particle size is controlled at 10-100 μm and compression force is optimized to ensure the powder flows sufficiently during processing while maintaining its ability to disintegrate and dissolve.
3Stability of the object's composition
If chemical additives are used to improve formulation characteristics, then stability and appearance are enhanced, but formulation purity and health safety deteriorate
Solution Approach 1:
The patent removes all chemical additives including preservatives, flavoring agents, artificial colors, and disintegrating agents from the formulation. The active ingredient powder is processed and formulated without any artificial substances, thereby maintaining 100% formulation purity while achieving stability through proper processing and packaging.
4Device complexity
If active powder is used directly, then formulation simplicity is maintained, but flowability and workability deteriorate
Solution Approach 1:
The patent optimizes the physical parameters of the active ingredient powder to improve flowability without changing its fundamental nature. Particle size is controlled at 10-100 μm, moisture content is optimized, and compression parameters are adjusted to ensure the powder flows adequately during processing while maintaining formulation simplicity.
Solution Approach 2:
The patent performs preliminary processing of the active ingredient powder before pellet manufacturing, including particle size reduction, moisture control, and pre-compression. These preliminary actions prepare the powder for adequate flowability and workability in subsequent pellet formation steps without adding chemical substances.
Data Source
AI summary
Disclosed herein is an active pellet. The active pellet includes a body and interspaces. The body includes an active ingredient ranging from 50 to 100 wt %, free of chemical additives.