Adenosine Phosphate O/W Emulsion Composition for High Viscosity Stability

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Solution Overview

Problem

Existing O/W emulsion compositions containing adenosine phosphate and acrylic acid-alkyl methacrylate copolymer struggle with achieving high viscosity (≥10,000 mPa·s) while maintaining good emulsification stability.

Innovation Solution

Incorporating specific water-soluble polymers, such as urethane associative thickeners, and pH adjusters, along with uncrystallized high melting point oils and oil-based gelling agents, to enhance emulsification stability and improve the feel during use.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Force

If adenosine phosphate and acrylic acid-alkyl methacrylate copolymer are used to create high viscosity O/W emulsion, then viscosity increases to ≥10,000 mPa·s, but emulsification stability deteriorates

Engineering Contradiction:
ImproveviscosityVSAvoidemulsification stability
Core Design Contradiction:
ForceVSStability of the object's composition

Solution Approach 1:

The patent introduces a specific intermediary substance (polyglyceryl-3 distearate) as a mediator between the adenosine phosphate/acrylic acid-alkyl methacrylate copolymer system and the emulsion droplets. This intermediary substance acts as a bridge that maintains emulsification stability while allowing the high viscosity characteristics to be preserved, directly resolving the contradiction between viscosity and emulsification stability

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates a composite emulsion system by combining multiple ingredients with complementary functions: adenosine phosphate for moisturizing, acrylic acid-alkyl methacrylate copolymer for viscosity and emulsion formation, and polyglyceryl-3 distearate for stabilizing the emulsion interface. This composite approach allows the system to achieve high viscosity while maintaining emulsification stability through the synergistic interaction of components

Inventive Principle:
Principle #40Composite materials

Data Source

PatentEP3960246B1High viscosity o/w emulsion composition containing adenosine phosphate
Publication Date: 2026.04.22 OTSUKA PHARM CO LTD
  • EP3960246B1 patent drawingFigure 1

AI summary

The present disclosure provides an O/W emulsion composition, comprising an adenosine phosphate and/or a salt thereof; an acrylic acid-alkyl methacrylate copolymer; an oil content; and water; and comprising a water-soluble polymer selected from a swelling thickener, an associative thickener, a polysaccharide and a derivative thereof, and a mixture thereof, and/or a pH adjuster which is an organic alkali compound; wherein the composition has a viscosity of equal to or higher than 10,000 mPa·s.