Adhesion Promoting Base Layer for Lubricious Medical Coatings
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Solution Overview
Problem
Current lubricious coatings for medical devices face challenges in maintaining adhesion to hydrophobic substrates like polypropylene, FEP, and ETFE, leading to poor durability and high particulate release, which can be dangerous during procedures like angioplasty and stent placement.
Innovation Solution
A lubricious coating comprising a base coating layer with a polymeric adhesion promoter and a crosslinked polymeric matrix, and a top lubricious layer formed by curing a hydrophilic curable polymer with a crosslinking agent, providing strong adhesion and minimizing particulate release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a hydrophilic polymer coating is applied to hydrophobic substrates (PP, FEP, ETFE), then lubricious performance is improved, but adhesion is poor and coating durability deteriorates
Solution Approach 1:
The coating is divided into two distinct layers: a base layer containing hydrophobic polymer and adhesion promoter applied first, followed by a top layer containing hydrophilic polymer for lubricious performance. This segmentation allows each layer to perform its specialized function without compromising the other, solving the adhesion-lubrication conflict.
Solution Approach 2:
An adhesion promoter component acts as an intermediary between the hydrophobic substrate and the hydrophilic top layer. This intermediary contains both hydrophobic groups (for substrate bonding) and hydrophilic groups (for top layer bonding), enabling strong interfacial adhesion across the hydrophobic-hydrophilic boundary.
2Ease of operation
If a single-layer hydrophilic coating is used, then lubricious performance is achieved, but adhesion to hydrophobic substrates is insufficient
Solution Approach 1:
The coating system is segmented into functional layers: a base layer with hydrophobic polymer and adhesion promoter for substrate bonding, and a top layer with hydrophilic polymer for lubrication. This resolves the contradiction by separating adhesion and lubrication functions into different layers.
Solution Approach 2:
The coating uses composite material structure combining hydrophobic polymer (for adhesion to hydrophobic substrates) and hydrophilic polymer (for lubricious performance). This composite approach allows simultaneous achievement of strong adhesion and excellent lubrication.
3Ease of operation
If hydrophilic polymer coating is applied to hydrophobic substrates without proper adhesion promotion, then lubricious performance is improved, but particulate release increases
Solution Approach 1:
The coating is segmented into a stable base layer that anchors to the substrate and a lubricious top layer that minimizes friction. This segmentation prevents the top layer from detaching and forming particulates, as the base layer provides strong anchoring.
Solution Approach 2:
The base layer with adhesion promoter is applied first to establish strong substrate bonding before applying the hydrophilic top layer. This preliminary action ensures the coating system is firmly anchored, preventing particulate release during device insertion and removal.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The coating achieves robust adhesion to a wide range of substrates, significantly reduces friction force, and minimizes particulate release, ensuring stability and safety during medical device insertion and removal.
Implementation Method 1
a polymeric adhesion promoter which is a block copolymer comprising hydrophobic and hydrophilic polymer blocks and/or a hydrophilic polymer comprising hydrophilic functional groups, where from 10% to 100% of the hydrophilic functional groups are capped with a hydrophobic functional group
Implementation Method 2
a first crosslinked polymeric matrix formed by a first monomeric or polymeric crosslinking agent
Implementation Method 3
a top lubricious layer formed by curing a hydrophilic curable polymer with a crosslinking agent
Implementation Method 4
Lubricious coatings are designed to provide medical devices with a slippery surface, which enhances the comfort of a subject during insertion, placement and/or removal of the medical device
Data Source
Figure 1(a)~2
Figure 3~4
Figure 5
AI summary
Described herein are coatings and formulations thereof for coating a substrate for use in producing a lubricious coating on a substrate surface that is to be inserted into the body lumen of a subject. Said coatings all contain an adhesion promoting coating formulation for applying to a substrate material that is formed from a polymeric adhesion promoter, a monomeric or polymeric crosslinking agent and a photoinitiator, where the polymeric adhesion promoter is a block copolymer comprising hydrophobic and hydrophilic polymer blocks and/or a hydrophilic polymer comprising hydrophilic functional groups, where from 10% to 100% of the hydrophilic functional groups are capped with a hydrophobic functional group and the formulations thereof further contain a solvent to enable the coating to be applied to a substrate surface.