Adhesive Composition Crystallization Inhibitor Tack

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Solution Overview

Problem

Existing adhesive compositions containing active agents face issues with crystallization, which leads to unpredictable release rates and compromised adhesive properties, particularly in medical applications where predictable and sustained delivery is crucial.

Innovation Solution

Incorporating a crystallization inhibitor, such as polyvinylpyrrolidone, into the adhesive composition in specific proportions along with an absorbent and vehicle, enhances adhesive properties like tack and adhesion while controlling the release of active agents, thereby maintaining effective adhesive performance and drug delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If crystallization inhibitors are incorporated into adhesive compositions containing active agents, then the release characteristics of actives become more predictable and stable, but adhesive properties such as tack and adhesion deteriorate

Engineering Contradiction:

Improvepredictability of active releaseVSAvoidadhesive properties

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The patent optimizes the concentration range of crystallization inhibitors (0.1-10 wt%) and adjusts formulation parameters such as adhesive resin type, vehicle composition, and processing conditions to achieve a balance where reliable active release is maintained while minimizing negative impacts on adhesive strength

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention uses composite adhesive formulations combining multiple resin types (e.g., polyisobutylene, styrene-isoprene-styrene block copolymer), crystallization inhibitors, vehicles, and optional absorbents to create a synergistic system that maintains both adhesive performance and controlled active release

Inventive Principle:

Principle #40Composite materials

2Reliability

If additional agents facilitating delivery of active agents are incorporated, then the effectiveness of actives improves, but adhesive properties of the composition are detrimentally impacted

Engineering Contradiction:

Improveeffectiveness of active deliveryVSAvoidadhesive properties

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The patent selects crystallization inhibitors that perform dual functions: they prevent active agent crystallization to ensure effective delivery while also being compatible with the adhesive matrix to maintain adequate adhesive properties. The formulation is designed so that a single additive system addresses both drug delivery and adhesive performance requirements

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Quantity of substance

If vehicles or solvents are used to solubilize active agents, then the active agents can be introduced into the adhesive, but the adhesive properties are inhibited and degraded

Engineering Contradiction:

Improvesolubility of active agentsVSAvoidadhesive properties

Core Design Contradiction:

Quantity of substanceVSStrength

Solution Approach 1:

The patent optimizes the type and concentration of vehicles (e.g., propylene glycol, polyethylene glycol, ethanol) within specific ranges (1-20 wt%) to maximize active agent solubility while minimizing disruption to the adhesive polymer matrix, thereby maintaining adhesive strength

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The formulation uses composite systems combining adhesive resins with compatible vehicles and crystallization inhibitors that work synergistically to maintain both high active agent solubility and preserved adhesive properties, creating a stable multi-component system

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The inclusion of crystallization inhibitors improves the solubility and stability of active agents, allowing for higher loadings and sustained release, while maintaining excellent adhesive properties, including increased tack and peel strength, and fluid handling capacity, making the compositions suitable for extended use on human skin.

Implementation Method 1

incorporate crystallization inhibitors in adhesive compositions that contain active agents. Without crystallization inhibitors, crystallization of the active agents contained in the adhesive may occur

Methodology Applied

Scientific EffectCrystallization inhibition: Crystallisation

Implementation Method 2

Absorbents may be used in the compositions to absorb, retain, or transmit moisture or aqueous agents

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Data Source

PatentUS11717593B2Improving adhesive properties

Publication Date: 2023.08.08 AVERY DENNISON CORP

AI summary

Various adhesive compositions are described which may optionally comprise one or more active agents such as pharmaceutical agents. The incorporation of one or more absorbents in combination with one or more crystallization inhibitors improves adhesive characteristics of the compositions. Also described are related methods of improving adhesive characteristics of adhesive compositions with the use of a combination of absorbent and inhibitor. Also described are related methods of using the compositions and articles incorporating such compositions.