Adhesive Dendritic Particles for Sustained Target-Site Delivery
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Solution Overview
Problem
Existing particle-based drug delivery systems fail to provide prolonged delivery of active agents to specific body locations due to their inability to remain in desired areas for an appreciable time.
Innovation Solution
Adhesive dendritic particles with a polymeric phase and dendrites are developed, allowing for sustained adhesion and release of active ingredients at targeted locations, such as teeth and biofilms, through emulsion formation using amphiphilic block copolymers like PEG-b-PLGA.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If existing particle-based drug delivery systems are used, then the system is simple and easy to manufacture, but the particles cannot remain in the desired location for an appreciable amount of time
Solution Approach 1:
The particle surface is segmented with dendritic structures that extend from the core particle. These dendrites create multiple attachment points for adhesion to target surfaces, significantly improving residence time and reliability of sustained delivery compared to smooth particles.
Solution Approach 2:
The adhesive particles dynamically adjust their adhesion strength through environmental responses such as pH changes or enzymatic degradation. This allows the particles to maintain strong adhesion during circulation and then release controlled amounts of drug over extended periods at the target site.
2Duration of action of moving object
If adhesive dendritic particles are used to achieve prolonged delivery, then the duration of action is improved, but the device complexity increases
Solution Approach 1:
The particle structure is organized in nested layers: a core particle contains dendritic structures that extend outward, with active ingredients embedded within the dendrites and/or core. This nested architecture enables prolonged delivery while maintaining a relatively simple fabrication process using sequential emulsification.
Solution Approach 2:
The adhesive particle is constructed as a composite system combining a polymeric core with dendritic surface structures. This composite design provides both the mechanical stability needed for circulation and the adhesive properties required for prolonged residence, achieving extended delivery without excessive complexity.
3Ease of operation
If particles circulate freely throughout the body, then the system is simple to administer, but the particles do not remain in their desired location
Solution Approach 1:
The adhesive particles self-adhere to target surfaces through their dendritic structures without requiring external intervention or complex targeting mechanisms. This self-service adhesion capability maintains ease of administration while enabling prolonged retention at the desired location through passive attachment to tissue surfaces.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive dendritic particles effectively adhere to and release active ingredients at targeted sites, providing prolonged and controlled delivery, enhancing the persistence of therapeutic effects.
Implementation Method 1
the adhesive dendritic particle being configured to adhere to a location of a subject so as to allow for release of at least one active ingredient to the location
Implementation Method 2
allow for release of at least one active ingredient from the adhesive dendritic particle at the location
Data Source
AI summary
Provided are adhesive dendritic particles, which particles can be used for sustained delivery of an active agent to a location or locations at which the particles are adhered. Also provided are related methods of use and methods of formulating the disclosed particles.