Adhesive Material with Dynamic Viscosity for Skin Patches
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Solution Overview
Problem
Existing adhesive preparations for continuous drug administration from the skin surface face challenges in maintaining adhesiveness while minimizing skin irritation during peeling, often resulting in reduced adhesive force and premature detachment.
Innovation Solution
An adhesive material with an adhesive layer laminated on a support, featuring two synthetic rubbers with different flowability and an apparent viscosity of 0.2×10^4 to 10×10^4 Pa·s, along with a tackifier and organic liquid, to achieve suitable adhesiveness and easy peeling without skin irritation after a desired period.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If emphasis is placed on suppression of physical stimulation upon peeling off, then skin irritation is reduced, but adhesive force is unnecessarily reduced leading to premature detachment
Solution Approach 1:
The adhesive layer's viscosity dynamically changes with temperature: at low temperatures (storage and initial adhesion) it maintains high viscosity for strong adhesion, while at high temperatures (body temperature during peeling) it becomes less viscous for easy removal. This dynamic property resolves the contradiction between maintaining strong adhesive force and enabling easy peeling without skin irritation.
Solution Approach 2:
The invention changes the physical parameter of viscosity by controlling temperature. The adhesive layer is designed with specific viscosity characteristics at different temperatures: high viscosity at room temperature for strong bonding, and reduced viscosity at body temperature for painless removal. This parameter change allows the same adhesive material to provide both strong adhesion and easy peeling.
2Reliability
If adhesive force is maintained at high levels, then preparation remains attached during effective period, but peeling off causes skin irritation and damage
Solution Approach 1:
The adhesive layer exhibits dynamic viscosity behavior that adapts to temperature changes. During the effective period at body temperature, the adhesive maintains appropriate bonding strength. Upon removal, the temperature difference triggers viscosity reduction, enabling painless peeling without skin damage, thus resolving the contradiction between reliable adhesion and gentle removal.
Solution Approach 2:
The adhesive material undergoes periodic state changes based on temperature exposure. During application and wear, it exists in a high-viscosity bonded state. During removal, the temperature change induces a transition to a lower-viscosity state, creating distinct operational phases that separate the adhesion function from the removal function.
3Ease of operation
If adhesive layer is designed for easy peeling, then skin irritation is suppressed, but adhesive force is reduced causing premature falling off
Solution Approach 1:
The adhesive layer's viscosity is dynamically controlled through temperature dependence. At application and storage temperatures, it maintains high viscosity for reliable adhesion. At body temperature during peeling, viscosity decreases to facilitate easy removal without skin irritation, thus achieving both strong adhesion and easy peeling.
Solution Approach 2:
The invention utilizes temperature as a control parameter to switch the adhesive layer's properties. The viscosity parameter changes from high (for strong adhesion) to low (for easy peeling) based on temperature exposure, allowing the same material to provide both strong bonding and easy removal characteristics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive material maintains effective adhesiveness for a specified time without causing skin irritation and allows easy peeling without pain or physical irritation, ensuring sustained drug absorbability and prolonged adhesion periods of 1 to 3 days.
Implementation Method 1
the adhesive layer has an apparent viscosity at 30° C. of 0.2×10^4 to 10×10^4 Pa·s and comprises two kinds of synthetic rubbers having different flowability
Data Source
AI summary
The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.