Adhesive Nanogel Coating via Pre-Crosslinked Self-Assembly
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Solution Overview
Problem
Current methods for producing polyacrylic acid-based nanogels are complex and laborious, limiting their cost-effective production and effectiveness, particularly in biomedical applications, due to the need for multiple steps and potential incomplete functionalization which affects their antimicrobial activity.
Innovation Solution
A simple process involving pre-cross-linked polyacrylic acid nanoparticles suspended in an aqueous or alcoholic solution with bioactive molecules and pharmaceutically acceptable excipients, which self-assemble to form an adhesive nanogel coating upon evaporation, providing a stable and effective antimicrobial surface coating.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If complex multistep preparation processes are used for polyacrylic acid-based nanogels, then nanogel formation is achieved, but manufacturing complexity and labor requirements increase significantly
Solution Approach 1:
The patent applies preliminary action by pre-crosslinking polyacrylic acid nanoparticles before use. The nanoparticles are pre-prepared with controlled crosslinking, then simply suspended in aqueous or alcoholic solutions with bioactive molecules to form the final nanogel composition. This eliminates the need for complex multistep preparation processes while ensuring reliable nanogel formation, as the crosslinking structure is already established in the pre-crosslinked nanoparticles.
2Reliability
If multiple preparation steps are used for nanogel functionalization, then nanogel structure is formed, but production time and labor costs increase
Solution Approach 1:
The patent merges multiple preparation steps into a single suspension process. Pre-crosslinked polyacrylic acid nanoparticles are directly suspended in solutions containing bioactive molecules, excipients, and solvents to form the complete nanogel composition in one step. This combining of steps maintains reliable nanogel structure formation while dramatically reducing production time and eliminating sequential operational complexity.
3Ease of manufacture
If incomplete functionalization is used to simplify the process, then preparation complexity decreases, but antimicrobial effectiveness is reduced
Solution Approach 1:
The patent applies preliminary action by pre-functionalizing the polyacrylic acid nanoparticles with bioactive molecules during the pre-crosslinking stage. This ensures complete and uniform functionalization is achieved in advance, so that when the nanoparticles are suspended to form the final composition, the antimicrobial effectiveness is already optimized. The bioactive molecules are incorporated into the nanoparticle structure during pre-preparation, guaranteeing reliable antimicrobial activity while keeping the final formulation process simple.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive nanogel composition effectively coats surfaces, providing long-lasting antimicrobial protection by releasing bioactive molecules in response to pH and moisture, maintaining efficacy for over 30 days on non-living surfaces and several hours on living skin.
Implementation Method 1
pre-cross-linked polyacrylic acid nanoparticles suspended in an aqueous or alcoholic solution with bioactive molecules and pharmaceutically acceptable excipients, which self-assemble to form an adhesive nanogel coating upon evaporation
Implementation Method 2
self-assemble to form an adhesive nanogel coating upon evaporation
Implementation Method 3
releasing bioactive molecules in response to pH and moisture
Implementation Method 4
releasing bioactive molecules in response to pH and moisture
Implementation Method 5
adhesive nanogel composition effectively coats surfaces
Data Source
AI summary
The present invention relates to an adhesive nanogel composition comprising of bioactive molecules, pre cross-linked polyacrylic acid nanoparticles (pre cross-linked nanoparticles suspension form of carbomer), and pharmaceutically or cosmetically acceptable excipient(s). The present invention also relates to a process for preparation of the adhesive nanogel composition and use of the adhesive nanogel composition as long lasting hand sanitizer or disinfectant of living or non-living surfaces.