Adhesive Patch with DMSO for Rapid Anesthesia

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Solution Overview

Problem

Current local anesthetic patches face challenges such as complex application procedures, potential skin damage, stickiness, and inadequate anesthesia duration, with a lack of rapid onset and sufficient potency, particularly for lidocaine and prilocaine mixtures.

Innovation Solution

A patch comprising an adhesive layer with a local anesthetic, a thermoplastic elastomer, a higher fatty acid ester, and dimethyl sulfoxide, which allows for simple application and rapid onset of anesthesia.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a local anesthetic cream is used to achieve sufficient anesthesia, then the anesthetic potency is improved, but the application procedure becomes complex and involves multiple steps

Engineering Contradiction:

Improveanesthetic potencyVSAvoidapplication procedure

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines the local anesthetic (lidocaine and/or prilocaine) directly into the adhesive layer of the patch, merging the medication function with the adhesive function. This eliminates the need for separate cream application and occlusive dressing steps, as the anesthetic is already integrated in the patch structure that simply needs to be applied to the skin.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patch serves multiple functions simultaneously: it acts as an adhesive bandage, delivers local anesthetic medication, and provides occlusive effect through its structure. The adhesive layer contains both the adhesive components and the local anesthetic, making the patch a multi-functional device that replaces multiple separate products and procedures.

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Reliability

If a local anesthetic cream is applied thickly to ensure adequate dosage, then the anesthetic effect is improved, but skin damage risk and cleanup complexity increase

Engineering Contradiction:

Improveanesthetic effectVSAvoidskin damage risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent controls the concentration and distribution of the local anesthetic within the adhesive layer, ensuring adequate dosage without requiring thick application. The anesthetic is formulated at appropriate concentrations within the adhesive matrix, allowing controlled delivery that achieves sufficient effect while minimizing skin damage risk associated with excessive cream application.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patch is designed as a disposable single-use product that is applied and then removed without needing cleanup. The adhesive layer contains the complete anesthetic dosage required, and after use, the entire patch is discarded rather than requiring wiping or cleaning of residual cream from the skin.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Ease of operation

If a local anesthetic patch is applied for a short duration to achieve rapid onset, then the ease of operation is improved, but the anesthetic potency is insufficient

Engineering Contradiction:

Improveapplication simplicityVSAvoidanesthetic potency

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent optimizes multiple parameters including the concentration of local anesthetic in the adhesive layer, the amount of anesthetic per unit area, the adhesive properties for secure attachment, and the physical structure to ensure adequate drug delivery. These parameter adjustments ensure that sufficient anesthetic potency is achieved even with shorter application times compared to conventional creams.

Inventive Principle:

Principle #35Parameter changes

4Speed

If the adhesive layer contains high concentration of local anesthetic for rapid onset, then the onset speed is improved, but the skin permeability control becomes more difficult

Engineering Contradiction:

Improveonset speedVSAvoidskin permeability control

Core Design Contradiction:

SpeedVSManufacturing precision

Solution Approach 1:

The adhesive layer is formulated as a composite material containing adhesive components, local anesthetic (lidocaine and/or prilocaine), and other excipients in specific proportions. This composite structure allows the anesthetic to be delivered at high concentration while maintaining proper skin permeability through the engineered adhesive matrix that controls drug release and penetration.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The patch achieves a rapid and sufficient level of anesthesia with improved skin permeability and reduced application complexity, enhancing user experience and efficacy.

Implementation Method 1

dimethyl sulfoxide...achieving a rapid onset of anesthesia

Methodology Applied

Scientific EffectSkin permeation enhancement: Permeation

Implementation Method 2

an adhesive layer on the support, where the adhesive layer includes a local anesthetic, a thermoplastic elastomer, a higher fatty acid ester

Methodology Applied

Scientific EffectAdhesion: Adhesive

Data Source

PatentUS20250009682A1patch

Publication Date: 2025.01.09 KANEKA CORP

AI summary

A patch includes a support and an adhesive layer on the support. The adhesive layer includes a local anesthetic, a thermoplastic elastomer, a higher fatty acid ester, and dimethyl sulfoxide.