Adhesive Patch Mixed Hydrocarbon Rubber Silicone Polymer
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Solution Overview
Problem
Conventional adhesive patches have low skin permeability and high fat solubility, leading to insufficient drug absorption and skin irritation, making them ineffective for percutaneous administration, especially for ambroxol hydrochloride, which requires sustained release to maintain therapeutic efficacy throughout the night.
Innovation Solution
An adhesive patch with a mixed adhesive base containing hydrocarbon rubber and silicon-containing polymer, specifically a stylene-isoprene-stylene block copolymer and polydimethyl siloxane, enhances skin permeability and stability, allowing for effective percutaneous absorption of ambroxol hydrochloride.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional adhesive bases are used in adhesive patches, then the adhesive patch can be manufactured, but the skin permeability and drug absorption are insufficient
Solution Approach 1:
The patent uses a composite adhesive base consisting of acrylic polymer and rubber polymer in specific proportions (acrylic polymer 10-70 parts by weight, rubber polymer 30-90 parts by weight). This composite structure combines the advantages of both materials: acrylic polymer provides good skin adhesion while rubber polymer enhances drug permeability through its lipophilic properties that can penetrate the cornified layer more effectively
Solution Approach 2:
The patent optimizes the weight ratio parameters of the adhesive base components to achieve optimal drug absorption. By adjusting the proportion of acrylic polymer to rubber polymer within specific ranges, the formulation achieves the right balance between adhesion strength and permeability enhancement, allowing sufficient drug delivery through the skin barrier
2Reliability
If conventional adhesive patches are used, then they can be applied to skin, but they cause skin irritation and aging instability of the drug
Solution Approach 1:
The patent specifies precise parameter ranges for adhesive base components and additives to minimize skin irritation while maintaining drug stability. The controlled composition (specific ratios of acrylic and rubber polymers, limited antioxidants and plasticizers) ensures the adhesive remains stable over time without degrading the drug or causing excessive skin reactions
Solution Approach 2:
The adhesive patch is designed as a disposable single-use product with optimized composition that prevents long-term degradation issues. The formulation includes appropriate antioxidants (0.1-5 parts by weight) to prevent drug oxidation during the patch's wear period, ensuring stability without requiring complex long-term preservation systems
3Reliability
If oral administration methods are used for ambroxol, then the drug can be administered easily, but decomposition and metabolism occur reducing therapeutic efficacy
Solution Approach 1:
The adhesive patch acts as an intermediary delivery system that bypasses the digestive tract and liver metabolism associated with oral administration. By delivering ambroxol directly through the skin into systemic circulation, the patch avoids first-pass metabolism and gastrointestinal decomposition, maintaining higher therapeutic efficacy while providing a convenient non-invasive application method
4Reliability
If sustained-release capsules are used for ambroxol, then therapeutic effects are improved, but administration difficulty increases for elderly and pediatric patients
Solution Approach 1:
Instead of requiring patients to swallow capsules (traditional oral route), the invention inverts the administration approach by applying the medication topically to the skin. This eliminates the swallowing barrier for elderly and pediatric patients while achieving sustained-release therapeutic effects through controlled percutaneous absorption of ambroxol over time
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive patch achieves superior skin absorbability and stability, ensuring sustained drug efficacy with reduced skin irritation, improving compliance and ease of administration for ambroxol hydrochloride, particularly beneficial for elderly and pediatric patients.
Implementation Method 1
the cornified layer has extremely high fat solubility and low skin permeability of a drug in general... to increase the skin absorbability of a drug in percutaneous administration using adhesive patches
Implementation Method 2
an adhesive layer which contains ambroxol hydrochloride and a mixed adhesive base that contains a hydrocarbon rubber and a silicon-containing polymer
Data Source
AI summary
The present invention relates an adhesive patch comprising a backing layer and an adhesive layer that contains a drug, wherein the adhesive layer contains a mixed adhesive base containing a hydrocarbon rubber and a silicon-containing polymer. The adhesive patch of the invention shows extremely superior skin absorbability of a drug in a preparation, reduced skin irritation, and excellent aging stability of the drug in the preparation, and can achieve easiness of drug-taking methods and improvement in compliance.