Adhesive Patch Layered Structure Oozing Prevention
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Solution Overview
Problem
Adhesive patches and preparations face issues with adhesive layer oozing or protruding, leading to difficulties in packaging, skin adhesion, and release liner detachment, which affects their usability and effectiveness.
Innovation Solution
The adhesive patch design features a lateral end of the adhesive layer positioned towards the central part from the support, with a distance between the support and release liner greater than the adhesive patch's central thickness, preventing oozing and protrusion, and allowing easy detachment of the release liner.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the adhesive layer is made thick to protect the wound surface and ensure effective drug content, then the wound protection and drug delivery are improved, but the adhesive layer easily oozes or protrudes from the end of the adhesive patch, causing cold flow and adhesion problems
Solution Approach 1:
The adhesive layer is divided into a first adhesive layer and a second adhesive layer with different properties. The first adhesive layer has lower viscosity and provides initial adhesion, while the second adhesive layer has higher viscosity and prevents cold flow, thereby maintaining both wound protection and preventing adhesive oozing.
Solution Approach 2:
Different regions of the adhesive layer are given different viscosities through the two-layer structure. The first adhesive layer near the application surface has lower viscosity for good adhesion, while the second adhesive layer deeper in the structure has higher viscosity to prevent cold flow and maintain structural integrity.
2Quantity of substance
If the adhesive layer is made thick to ensure effective drug content, then the drug delivery is improved, but the end of the adhesive patch is easily rubbed against clothes and turned up, causing adhesion problems
Solution Approach 1:
The adhesive layer is segmented into two layers with different viscosities. The first adhesive layer provides initial adhesion and drug delivery, while the second adhesive layer with higher viscosity prevents the adhesive patch from turning up and maintains stable attachment to the skin.
Solution Approach 2:
The adhesive system uses a composite structure of two adhesive layers with different rheological properties. This composite adhesive layer combines the benefits of low viscosity (good adhesion and drug delivery) and high viscosity (prevents turning up and maintains stability).
3Reliability
If the adhesive layer is made thick to protect the wound surface, then the wound protection is improved, but the adhesive layer components ooze from the end of the adhesive patch, causing difficulty in taking out from package and staining during adhesion
Solution Approach 1:
The adhesive layer is divided into two layers where the first adhesive layer with lower viscosity ensures wound protection and drug delivery, while the second adhesive layer with higher viscosity acts as a barrier to prevent adhesive components from oozing out and causing staining or package adhesion.
4Object-generated harmful factors
If the end of the support covers the end of the adhesive layer to prevent oozing, then adhesive oozing is suppressed, but the release liner may not be easily detached from the end during use
Solution Approach 1:
The adhesive layer is given different viscosities at different depths through the two-layer structure. The first adhesive layer with lower viscosity allows easy release liner detachment, while the second adhesive layer with higher viscosity prevents oozing, thereby resolving the contradiction between preventing oozing and enabling easy release.
Data Source
AI summary
The present invention provides an adhesive patch comprising a support, an adhesive layer on at least one surface of the support, and a release liner on a surface of the adhesive layer opposite from the support, wherein(a) the lateral end of the adhesive layer is exposed,(b) in at least one lateral end, the lateral end of the adhesive layer is located toward the central part side of the adhesive patch from the lateral end of the support, and(c) when placed horizontally with the release liner facing down, a distance A between the upper end of the support and the lower end of the release liner at said lateral end of the adhesive patch is greater than a thickness B of the central part of the adhesive patch.