Adhesive Plaster Releasability Stabilization
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Solution Overview
Problem
Existing patches face challenges in maintaining adequate releasability of the release liner over time without altering the basic composition of the adhesive layer, which can affect adhesiveness to the skin and transdermal absorbability of drugs.
Innovation Solution
Incorporating 0.3 to 5% by mass of nonfunctional silicone oil with a kinematic viscosity of 10 to 350 cSt at 25°C into the adhesive layer, specifically using dimethylpolysiloxane, to adjust and stabilize the releasability of the release liner without impacting adhesiveness or drug permeability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If the release liner is made excessively easy to peel off from the adhesive layer, then the releasability is improved, but the release liner may move out of alignment with the adhesive layer during manufacturing or storage, causing insufficient protection of the adhesive layer
Solution Approach 1:
The patent applies release treatment to the surface of the release liner by coating it with a release agent (silicone-based or fluorine-based resin) and then fixing the coating through crosslinking. This chemical modification of the surface parameters creates an optimal balance between releasability and protection, allowing the release liner to be easily peeled off while remaining securely positioned during manufacturing and storage.
2Ease of operation
If the basic composition of the adhesive layer is changed to improve releasability from the release liner, then the releasability is improved, but the adhesiveness to the skin, transdermal absorbability, and temporal stability of the drug may be adversely affected
Solution Approach 1:
The patent separates the functions of the adhesive layer and the release liner by applying release treatment specifically to the surface of the release liner. This segmentation allows the adhesive layer's basic composition to remain unchanged, preserving its adhesiveness and drug stability, while the release liner's surface is independently modified to provide the desired releasability.
Solution Approach 2:
The release agent coating on the release liner acts as an intermediary layer that mediates between the adhesive layer and the external environment. This intermediate coating provides the releasability function without requiring changes to the adhesive layer's composition, thus maintaining adhesiveness and drug stability while enabling easy removal of the release liner.
3Ease of operation
If release treatment is applied to the release liner surface, then the releasability is improved, but the releasability tends to deteriorate over time
Solution Approach 1:
The patent applies release treatment to the release liner surface before the adhesive layer is applied. This preliminary action ensures that the release properties are established in advance, creating a stable foundation that prevents subsequent deterioration of releasability over time.
Solution Approach 2:
The crosslinking process fundamentally changes the chemical structure of the release agent coating, creating a stable, crosslinked network that resists degradation over time. This parameter change from linear polymer chains to crosslinked structures ensures that the releasability properties remain stable and do not deteriorate during storage and use.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively adjusts and maintains adequate releasability of the release liner, preventing bleeding and ensuring stable adhesiveness and drug permeability, even after storage, without changing the adhesive layer's composition.
Implementation Method 1
the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25°c
Implementation Method 2
nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25°c
Data Source
AI summary
A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25°C.