Tissue Regeneration Patch via Adipose Tissue Freezing
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Solution Overview
Problem
Current methods for treating diabetic foot disease and skin damage from burns are inadequate in promoting rapid and effective regeneration of damaged or lost skin tissue, leading to significant quality of life reduction for patients.
Innovation Solution
A method for manufacturing a tissue regeneration patch involving the preparation of micronized adipose tissue extract, injection into a mold of predetermined shape, cooling between −25° C. and −10° C., and removal to produce a customized patch for rapid tissue treatment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If adipose tissue extract is directly applied to damaged tissue, then the treatment process is simple, but the regeneration effectiveness and speed are insufficient
Solution Approach 1:
The patent applies phase transition by freezing the adipose tissue extract to form ice crystals, which then serve as a template structure for tissue regeneration. The freezing process transforms the liquid extract into a solid matrix that promotes cellular organization and regeneration, resolving the contradiction between simple application and effective regeneration.
Solution Approach 2:
The patent performs preliminary actions by pre-freezing the adipose tissue extract before application to the damaged tissue. This preliminary freezing step creates a structured matrix that enhances regeneration effectiveness, while the overall process remains simple and can be performed at the site of clinical intervention.
2Ease of manufacture
If adipose tissue extract is directly applied to damaged tissue, then the manufacturing process is simple, but the production speed and customization capability are limited
Solution Approach 1:
The freezing process creates ice crystals that rapidly form a structured matrix, enabling fast production of customized patches. The phase transition from liquid to solid occurs quickly, allowing rapid manufacturing of patient-specific patches at the site of clinical intervention.
Solution Approach 2:
The patent changes the physical state parameter of the adipose tissue extract from liquid to solid through freezing. This parameter change enables the extract to form a structured, customizable patch shape that can be rapidly produced and tailored to specific patient needs.
3Reliability
If conventional skin graft or amputation is performed, then the treatment is effective for severe burns, but the quality of life is significantly reduced and scarring occurs
Solution Approach 1:
The freezing process creates a unique matrix structure that promotes regenerative healing rather than scarring. The ice crystal template guides tissue formation to restore normal skin architecture, eliminating scarring and improving quality of life while effectively treating severe burns.
Solution Approach 2:
The frozen adipose tissue extract matrix serves itself by providing a self-organizing template that automatically guides tissue regeneration. The structure formed during freezing automatically creates the optimal architecture for healing without requiring external intervention, resulting in scar-free regeneration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enables simple and rapid production of a tissue regeneration patch that effectively promotes skin regeneration in damaged areas, particularly for diabetic foot disease and burns, with improved recovery rates and neovascularization compared to direct application of adipose tissue extract.
Implementation Method 1
cooling the mold into which the adipose tissue extract is injected at a temperature between −25° C. and −10° C.
Data Source
AI summary
The present invention method for manufacturing a tissue regeneration patch includes: A) preparing a micronized adipose tissue extract; B) injecting the micronized adipose tissue extract into a mold of a predetermined shape; C) cooling the mold into which the adipose tissue extract is injected at a temperature between −25° C. and −10° C.; and D) removing the mold to obtain a tissue regeneration patch.