Adipose Tissue Syringe with Porous Filter for In-Situ Filtration
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Solution Overview
Problem
Current methods for harvesting and processing adipose tissue for autologous transplantation are inefficient, complex, and often require pseudo-sterile centrifugation, leading to tissue trauma, blood loss, and high surgeon effort, with no standard techniques for large-scale isolation and refinement of liposuction-harvested adipose tissue.
Innovation Solution
A modular, disposable tissue sampling, processing, and injection syringe device with micro-pores that can be occluded or non-occluded, allowing for efficient aspiration, filtration, and re-injection of adipose tissue using a hand-held powered tissue aspiration instrument, minimizing cellular rupture and enabling gentle tissue handling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional liposuction techniques are used for tissue harvest, then adipose tissue can be procured, but the tissue contains unwanted components (oil, blood, anesthetic solution) and requires complex processing
Solution Approach 1:
The collection tube incorporates a porous filter membrane that allows unwanted components (oil, blood, anesthetic solution) to pass through while retaining adipose tissue. This filtering mechanism separates desired tissue from harmful contaminants without requiring complex external processing equipment.
Solution Approach 2:
The invention extracts and removes unwanted components (oil, blood, anesthetic solution) from the liposuction effluent through the porous filter, isolating only the纯净 adipose tissue needed for transplantation. This extraction process eliminates harmful factors while preserving the therapeutic substance.
2Quantity of substance
If centrifugation is used for tissue refinement, then tissue isolation is achieved, but tissue trauma and blood loss occur
Solution Approach 1:
The invention replaces the mechanical centrifugation system with a passive porous filtration system. Instead of using high-speed rotation and centrifugal force that cause tissue trauma, the porous filter membrane enables gentle separation based on size exclusion, allowing cells to pass through while retaining larger adipose tissue structures intact.
3Quantity of substance
If multiple processing steps are used for tissue refinement, then tissue purity is improved, but surgeon effort and time increase
Solution Approach 1:
The invention merges the collection and filtration functions into a single integrated collection tube with an embedded porous filter. This combination eliminates the need for separate processing steps and equipment, allowing surgeons to achieve tissue refinement during the initial aspiration process without additional time or effort.
Solution Approach 2:
The porous filter membrane performs automatic filtration of unwanted components as liposuction effluent passes through it, without requiring active surgeon intervention or additional processing steps. The system self-regulates to separate tissue from contaminants passively, reducing surgical complexity.
4Quantity of substance
If large-scale tissue harvest is performed, then sufficient tissue volume is obtained, but tissue refinement becomes more complex
Solution Approach 1:
The collection tube is segmented into distinct functional zones: an aspiration port for tissue intake, a porous filter membrane for separation, and a collection chamber for purified tissue storage. This segmentation allows each component to perform its specific function efficiently, enabling large-scale harvest with simplified processing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a more efficient, cost-effective, and sterile method for refining adipose tissue, reducing tissue trauma and surgeon effort, while allowing for high graft survival rates and flexible use in various clinical applications, including cosmetic and reconstructive procedures.
Implementation Method 1
The porous filter membrane allows fluid components to pass through while retaining adipose tissue
Data Source
AI summary
Tissue sampling, processing and injection syringe device and methods of filtering and concentrating cellular components of tissue sample in situ within the device.