Adjustable Irradiation Position for Accurate Tissue Analyte Detection
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Solution Overview
Problem
Existing analyte detection methods in tissue, particularly in human skin, face accuracy and reliability issues due to skin surface irregularities that affect the transmission of heat and pressure waves, especially in smaller devices.
Innovation Solution
A device with a measurement body and a controller that adjusts the irradiation position by moving the contact surface and excitation radiation axis transversally relative to each other, ensuring optimal transmission of heat and pressure waves to improve analyte detection accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a fixed irradiation position is used on the skin surface, then the device structure is simple, but the detection accuracy deteriorates due to skin surface irregularities affecting heat and pressure wave transmission
Solution Approach 1:
The patent implements a movable contact surface relative to the excitation radiation source, allowing the irradiation position to be dynamically adjusted across multiple locations on the skin surface. This dynamic positioning capability enables the system to overcome fixed-position limitations caused by skin irregularities while maintaining a relatively compact device structure through controlled mechanical movement.
Solution Approach 2:
The system performs preliminary scanning or positioning actions to identify optimal irradiation locations on the skin surface before conducting the actual analyte detection. This preliminary action allows the device to pre-adjust the contact surface position to areas with better thermal and acoustic coupling, thereby improving measurement accuracy without requiring complex real-time adjustment mechanisms during detection.
2Reliability
If the contact surface is moved transversally to the excitation radiation axis, then the transmission of heat and pressure waves is improved, but the device complexity increases
Solution Approach 1:
The contact surface is designed to move transversally relative to the excitation radiation propagation axis, creating a dynamic scanning mechanism that improves thermal and acoustic coupling with the skin. This movement allows the system to find optimal contact regions while maintaining a manageable device structure through coordinated motion control rather than complex mechanical redesign.
Solution Approach 2:
The movable contact surface acts as an intermediary element between the excitation radiation source and the skin tissue, mediating the transmission of heat and pressure waves. By allowing this intermediary to move transversally, the system optimizes the coupling interface without requiring fundamental changes to the radiation source or tissue interface design.
3Reliability
If a fixed measurement position is used, then the device operation is simple, but the detection reliability deteriorates due to skin surface irregularities
Solution Approach 1:
The system incorporates dynamic position adjustment of the contact surface relative to the skin, enabling automatic adaptation to skin irregularities. This dynamic capability improves detection reliability by allowing the system to scan and select optimal measurement locations, while the automation of this process maintains operational simplicity through programmed control sequences.
Solution Approach 2:
The device performs self-adjustment of the measurement position by automatically scanning or moving the contact surface to find optimal contact regions on the skin. This self-service capability allows the system to compensate for skin irregularities autonomously without requiring manual repositioning by the operator, thereby maintaining ease of operation while improving reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the accuracy and reliability of analyte detection by compensating for skin surface irregularities, allowing for precise measurement of analytes like glucose in interstitial fluid.
Implementation Method 1
irradiating excitation radiation into the tissue to be absorbed by the analyte contained therein
Implementation Method 2
heat and/or pressure waves generated by absorption of excitation radiation in the tissue
Implementation Method 3
heat and/or pressure waves generated by absorption of excitation radiation in the tissue to be transferred to said measurement body
Implementation Method 4
heat and/or pressure waves generated by absorption of excitation radiation in the tissue to be transferred to said measurement body
Data Source
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AI summary
Disclosed herein is a device and a method for detecting an analyte in tissue of a human or animal subject. The device (100) comprises a measurement body (16) having a contact surface (14) suitable to be brought in contact with a skin surface (108) of the subject, said contact permitting heat and/or pressure waves generated by absorption of excitation radiation in the tissue to be transferred to said measurement body (16); an excitation radiation source (26) configured for irradiating excitation radiation at a plurality of wavelengths into the tissue to be absorbed by the analyte contained therein; a detection device for detecting a physical response of the measurement body (16) or of a component included therein to a heat and/or pressure wave received from the tissue upon absorption of the excitation radiation and for generating a response signal based on said detected physical response, said response signal being indicative of a degree of absorption of excitation radiation; and a controller to control the excitation radiation source to irradiate excitation radiation into the tissue to be absorbed by the analyte contained therein and to control the detection device to detect said physical response and to generate a response signal indicative of the degree of absorption of said excitation radiation. The device further comprises means (118) configured to move said contact surface (14) and a propagation axis (112) of the excitation radiation irradiated into the tissue transversally with respect to each other while the contact surface (14) is in contact with the skin surface (108) of the subject to adjust an irradiation position (116) on the skin surface at which said excitation radiation is to be irradiated into the tissue.