Adjustable Shaft Mixing Receptacle for Biopharmaceutical Fluids
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Solution Overview
Problem
Geometric tolerance issues during manufacturing and thermal expansion in mixing containers for biopharmaceutical fluids lead to poor positioning of magnetic disks, causing malfunction and potential damage, making adjustment of the motor position challenging and prone to stress on components.
Innovation Solution
A mixing container with an adjustable shaft length and a dual-bearing system, where the first bearing is positioned relative to the motor to allow magnetic rotation, and a second bearing is connected to the container wall, enabling optimal alignment and reducing stress on components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the motor is positioned too low, then the alignment between the first bearing and the motor is improved, but the shaft is subjected to excessive stress which can lead to bending or breakage
Solution Approach 1:
The motor position is made adjustable rather than fixed, allowing the system to adapt its configuration. The motor can be repositioned vertically along the container wall to achieve optimal alignment between the first bearing and the motor while maintaining appropriate stress levels on the shaft, thus resolving the contradiction between alignment precision and shaft strength.
2Measurement precision
If the motor is positioned too high, then the alignment between the first bearing and the motor is improved, but the container wall is subjected to excessive tensile stress which can cause degradation or tearing
Solution Approach 1:
The adjustable motor position allows the system to find an optimal balance point that provides sufficient alignment precision while avoiding excessive tensile stress on the container wall. By making the motor position variable, the system can adapt to different container configurations and avoid permanent damage to the container wall.
3Device complexity
If the motor position is fixed, then the device complexity is reduced, but the positioning precision of the magnetic discs is insufficient due to geometric tolerance variations
Solution Approach 1:
The motor is equipped with an adjustable positioning mechanism that allows vertical movement along the container wall. This dynamic adjustment capability compensates for geometric tolerance variations in the container and shaft assembly, ensuring precise alignment between the motor's magnetic disc and the shaft's magnetic disc without requiring overly complex fixed positioning structures.
4Reliability
If an axial clearance of 2mm is maintained between the first bearing and the motor magnetic disc, then the operation of the mixing container is improved, but the motor must be positioned higher which increases stress on the container wall
Solution Approach 1:
The adjustable motor position enables the system to maintain the necessary 2mm axial clearance for reliable operation while positioning the motor at an optimal height that avoids excessive tensile stress on the container wall. The motor can be precisely positioned to achieve the required clearance without compromising container wall integrity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration ensures proper alignment and operation of the mixing container, preventing damage and ensuring effective mixing of biopharmaceutical fluids by allowing for continuous adjustment of the shaft length and maintaining a rotational torque, even during thermal expansion.
Implementation Method 1
The shaft of the container comprises at the level of the first bearing a disc comprising magnets which can be placed opposite a similar disc connected to a motor thus allowing the magnetic rotation of the shaft under the effect of the motor
Implementation Method 2
during mixing and heating of the biopharmaceutical fluid, for example from temperatures of the order of 30-40 degrees Celsius, expansion of the plastic parts forming the mixing container can occur
Data Source
Figure 1~2
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AI summary
The invention relates to a method for assembling a mixer-container (1) intended for receiving a biopharmaceutical fluid (C) in which: a container (2) is provided, the container (2) including: a mixing device (7) including at least one shaft (8) having an adjustable length, and at least one first bearing (11) attached to the wall (3), the shaft (8) extending at least into the inner space (4) from the first bearing (11); a rigid outer device (18) that compresses the container (2) is provided; a drive motor (9) located outside the container (2) is provided; the first bearing (11) of the container (2) is placed so as to be spaced apart from the motor (9); the length of the shaft (8) is adjusted along the main axis (XX) by arranging the shaft (8) opposite the motor (9) to enable the motor (9) to rotate the shaft (8).